Naslov
3-Amino-2-methylquinazolin-4-(3H)-one Schiff bases synthesis - a green chemistry approach - a comparison of microwave and ultrasound promoted synthesis with mechanosynthesis

Autori
Komar, Mario ; Prašnikar, Fran ; Gazivoda Kraljević, Tatjana ; Aladić, Krunoslav ; Molnar, Maja

Izvornik
Current green chemistry. (2213-3461) 8 (2021), 1; 62-69

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
quinazolinone ; Schiff bases ; green chemistry ; microwaves ; ultrasound ; mechanosynthesis

Sažetak
A green chemistry methods are important modern pathways in synthetic chemistry with main advantages such as milder reaction conditions, shorter time and higher yields. A series of quinazolinone based Schiff bases (1−27) have been successfully synthesized by using green synthetic methods including microwave-assisted, ultrasound- assisted and mechanochemical synthesis, respectively. Desired compounds were prepared from 3-amino-2-methylquinazolin-4(3H)-one and substituted benzaldehydes with moderate to high yields (11−90%). Benzoxazinone and 3-amino-2- methylquinazolin-4(3H)-one, the precursors of Schiff bases, were prepared by microwave induced synthesis. The structures of all Schiff bases are confirmed by 1H and 13C NMR spectroscopy and mass spectrometry as well. A novelty of this research is the application and comparison of green chemistry methods in the synthesis of desired compounds are listed above. The simplicity of synthesis includes ethanol as solvent and no need for further purification.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Prehrambena tehnologija

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