Naslov
Preparation of pyrrolopyrimidine and pyrrolopyridine derivatives as ASK1 inhibitors

Autori
Amantini, David ; Mesic, Milan ; Saxty, Gordon ; Poljak, Tanja ; Vujasinovic, Ines ; Ziher, Dinko ; Witty, David ; Gibson, Karl Richard

Broj patenta
WO2019/012284A1

Godina
2019

Datum patenta
(17.01.2019.)

Nositelj prava
GALAPAGOS NV ; CALCHAN (GB). LIMITED, London, Mechelen, Zagreb, BE

Sažetak
The present invention relates to pyrrolopyrimidine compounds according to Formula (I) and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASKl inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical com © positions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.

Izvorni jezik
Engleski

POVEZANOST RADA