Naslov
Hyperferritinemia and COVID-19?

Autori
Čepelak, Ivana ; Dodig, Slavica ; Vučenik, Ivana

Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 544 (2020), 52-53; 18-25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
hiperferitinemija ; COVID-19 ; upala ; metabolizam željeza ; feritin
(hyperferritinemia ; COVID-19 ; inflammation ; iron metabolism ; ferritin)

Sažetak
It has been repeatedly described that increased serum ferritin concentration or hyperferritinemia is as- sociated with COVID- 19, especially with more severe forms of this disease. Ferritin is a molecule whose concentration is determined as a marker of reflecting the body’s iron supply and less significantly as a marker of inflammation of infectious and non- infectious origin. The expression of this vital molecule for iron metabolism is therefore regulated, primarily by an iron- dependent mechanism. However, in addition to this regulation, there appears to be feedback between ferritin and cytokines in the control of pro-inflammatory and anti-inflammatory mediators. This review paper includes basic data on ferritin and the potential causes and consequences of hyper- ferritinemia with implications for COVID-19.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA