Naslov
Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males

Autori
Podobnik, Josip ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Dodig Ćurković, Katarina ; Ćurkovic, Mario ; Kovač, Vlatka ; Švob Štrac, Dubravka ; Čusek, Melita ; Bortolato, Marco ; Pivac, Nela

Izvornik
Biomolecules (2218-273X) 10 (2020), 11; 1555, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
juvenile correctional facility ; delinquent behavior ; platelet MAO-B activity ; MAOB rs1799836 polymorphism ; conduct disorder

Sažetak
Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO- B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building on this evidence, we assessed whether conduct disorder (CD), juvenile delinquency adjudications, or detention in a correctional facility were associated with either platelet MAO- B activity or the MAOB rs1799836 polymorphism. The study enrolled 289 medication-free male youths, including 182 individuals detained in a correctional facility (with or without a diagnosis of CD). Of the remaining 107 participants, 26 subjects had a diagnosis of CD, and 81 were mentally healthy controls. Platelet MAO-B activity was determined by spectrophotofluorometry, while MAOB rs1799836 was genotyped using qPCR. Platelet MAO-B activity, corrected for age and smoking, was significantly higher in juvenile detainees (p < 0.001), irrespective of CD diagnosis. MAOB rs1799836 was not associated with platelet MAO-B activity or with detention in a correctional facility, CD diagnosis, or delinquent behavior. These data suggest that detention in a juvenile correctional facility increases platelet MAO-B activity in male adolescents. Future studies are needed to determine the mechanisms and functional significance of MAO-B peripheral elevation in juvenile male detainees

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Psihologija

POVEZANOST RADA