Naslov
Molecules, mechanisms, and disorders of self- domestication: keys for understanding emotional and social communication from an evolutionary perspective

Autori
Šimić, Goran ; Vukić, Vana ; Kopić, Janja ; Krsnik, Željka ; Hof, Patrick R.

Izvornik
Biomolecules (2218-273X) 11 (2021), 1; 2, 39

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
chemoattractants ; chemorepellents ; epithelial-mesenchymal transition (EMT) ; extracellular matrix molecules ; fibroblast growth factor (FGF) ; methyl-CpG-binding protein 2 (MeCP2) ; neural crest cells (NCCs) ; self-domestication ; thyroid hormones ; vascular endothelial growth factor (VEGF)

Sažetak
The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells dif-ferentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waarden-burg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as Williams-Beuren syndrome and schizophrenia that have the characteristics of hyper-domestication, and autism spectrum disorders, and 7dupASD syndrome that have the character-istics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed onto-genesis of humans, as well as for the understanding of evolution of mammals in general.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

POVEZANOST RADA