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Pregled bibliografske jedinice broj: 1098771

Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites

Faydy, Mohamed El; Dahaieh, Naoufal; Ounine, Khadija; Rastija, Vesna; Almalki, Faisal; Jamalis, Joazaizulfazli; Zarrouk, Abdelkader; Hadda, Taïbi Ben; Lakhrissi, Brahim
Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites // Chemical Data Collections, 31 (2021), 100593, 37 doi:10.1016/j.cdc.2020.100593 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites

Autori
Faydy, Mohamed El ; Dahaieh, Naoufal ; Ounine, Khadija ; Rastija, Vesna ; Almalki, Faisal ; Jamalis, Joazaizulfazli ; Zarrouk, Abdelkader ; Hadda, Taïbi Ben ; Lakhrissi, Brahim

Izvornik
Chemical Data Collections (2405-8300) 31 (2021); 100593, 37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
synthesis ; quinolin-8-ol ; docking ; POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site

Sažetak
Eight new 7-substituted quinolin-8-ol derivatives were synthesized in moderate to good yields through quinolin-8-ol, and secondary amines as the starting reagents. The struc- tures of the prepared compounds have been characterized by elemental analysis and 1 H/ 13 C NMR. The antimicrobial activity of this new series of heterocyclic compounds has been achieved "in vitro" against some bacterial strains by means of the disk method, and most of the tested compounds have shown comparable or greater antibacterial ac- tivity than nitroxoline (standard antibiotic). It was very motivating to observe that POM (Petra/Osiris/Molinspiration) bioinformatic analyses of compound 5 exhibited better an- tibacterial activity (MIC = 10 μg/mL against B. subtilis bacteria), and higher drug score (DS = 0.57) compared with Nitroxoline (DS = 0.47 ; MIC = 20 μg/mL). Molecular docking investigations were also conducted to investigate the binding affinities as well as interac- tions of some compounds with the target proteins.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA

Ustanove:
Fakultet agrobiotehničkih znanosti Osijek

Profili:

Avatar Url Vesna Rastija (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Faydy, Mohamed El; Dahaieh, Naoufal; Ounine, Khadija; Rastija, Vesna; Almalki, Faisal; Jamalis, Joazaizulfazli; Zarrouk, Abdelkader; Hadda, Taïbi Ben; Lakhrissi, Brahim
Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites // Chemical Data Collections, 31 (2021), 100593, 37 doi:10.1016/j.cdc.2020.100593 (međunarodna recenzija, članak, znanstveni)
Faydy, M., Dahaieh, N., Ounine, K., Rastija, V., Almalki, F., Jamalis, J., Zarrouk, A., Hadda, T. & Lakhrissi, B. (2021) Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites. Chemical Data Collections, 31, 100593, 37 doi:10.1016/j.cdc.2020.100593.
@article{article, author = {Faydy, Mohamed El and Dahaieh, Naoufal and Ounine, Khadija and Rastija, Vesna and Almalki, Faisal and Jamalis, Joazaizulfazli and Zarrouk, Abdelkader and Hadda, Ta\"{\i}bi Ben and Lakhrissi, Brahim}, year = {2021}, pages = {37}, DOI = {10.1016/j.cdc.2020.100593}, chapter = {100593}, keywords = {synthesis, quinolin-8-ol, docking, POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site}, journal = {Chemical Data Collections}, doi = {10.1016/j.cdc.2020.100593}, volume = {31}, issn = {2405-8300}, title = {Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites}, keyword = {synthesis, quinolin-8-ol, docking, POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site}, chapternumber = {100593} }
@article{article, author = {Faydy, Mohamed El and Dahaieh, Naoufal and Ounine, Khadija and Rastija, Vesna and Almalki, Faisal and Jamalis, Joazaizulfazli and Zarrouk, Abdelkader and Hadda, Ta\"{\i}bi Ben and Lakhrissi, Brahim}, year = {2021}, pages = {37}, DOI = {10.1016/j.cdc.2020.100593}, chapter = {100593}, keywords = {synthesis, quinolin-8-ol, docking, POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site}, journal = {Chemical Data Collections}, doi = {10.1016/j.cdc.2020.100593}, volume = {31}, issn = {2405-8300}, title = {Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites}, keyword = {synthesis, quinolin-8-ol, docking, POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site}, chapternumber = {100593} }

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