Naslov
Synthesis, characterization, biocomputational modeling and antibacterial study of novel pyran based on 8-hydroxyquinoline

Autori
Rbaa, Mohamed ; Hichar, Abdelhadi ; Dohare, Punjan ; Anouar, El Hassane ; Lakhrissi, Younes ; Lakhrissi, Brahim ; Berredjem, Malika ; Almalki, Faisal ; Rastija, Vesna ; Rajabi, Mohammadali ; Hadda, Taïbi Ben ; Zarrouk, Abdelkader

Izvornik
Arabian Journal for Science and Engineering (0022-2860) 46 (2021), 6; 5533-5542

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
8-hydroxyquinoline ; synthesis ; antibacterial activity ; drug design ; POM analyses

Sažetak
In this work, we report the synthesis of a new family of organic compounds based on 8- hydroxyquinoline using a simple and efficient method. The synthesized 8-hydroxyquinoline derivatives were characterized by analysis of 1H and 13C NMR, FT-IR spectral data and elemental analysis (EA). Their antibacterial activity is tested against Gram-positive strains [S. aureus (ATCC29213), V. parahaemolyticus (ATCC17802)] and Gram negative [E. coli (ATCC35218), P. aeruginosa (ATCC27853)] by the use of the agar diffusion technique. The obtained results showed that the synthesized 8-hydroxyquinoline derivatives have a potent antibacterial activity against the tested strains compared to Norfloxacin as a standard antibiotic. The results also reveal the effectiveness of these compounds at low concentrations, with a MIC of 1.00 μg/ml for compound 4a. Their antibacterial activity has also been optimized by bioinformatics studies (POM analyses). The experimental results are in relatively good agreement with the corresponding theoretical ones.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA