Naslov
Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community‐acquired pneumonia

Autori
Villafuerte, David ; Aliberti, Stefano ; Soni, Nilam J. ; Faverio, Paola ; Marcos, Pedro J. ; Wunderink, Richard G. ; Rodriguez, Alejandro ; Sibila, Oriol ; Sanz, Francisco ; Martin‐Loeches, Ignacio ; Menzella, Francesco ; Reyes, Luis F. ; Jankovic, Mateja ; et al.

Izvornik
Respirology (1323-7799) 25 (2019), 5; 543-551

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Enterobacteriaceae ; community-acquired pneumonia ; multidrug-resistance ; prevalence ; risk factors
(Enterobacteriaceae ; community-acquired pneumonia ; multidrug-resistance ; prevalence ; risk factors.)

Sažetak
Background and objective: Enterobacteriaceae (EB) spp. family is known to include potentially multidrug-resistant (MDR) microorganisms, and remains as an important cause of community- acquired pneumonia (CAP) associated with high mortality. The aim of this study was to determine the prevalence and specific risk factors associated with EB and MDR-EB in a cohort of hospitalized adults with CAP. Methods: We performed a multinational, point-prevalence study of adult patients hospitalized with CAP. MDR-EB was defined when ≥3 antimicrobial classes were identified as non-susceptible. Risk factors assessment was also performed for patients with EB and MDR-EB infection. Results: Of the 3193 patients enrolled with CAP, 197 (6%) had a positive culture with EB. Fifty-one percent (n = 100) of EB were resistant to at least one antibiotic and 19% (n = 38) had MDR-EB. The most commonly EB identified were Klebsiella pneumoniae (n = 111, 56%) and Escherichia coli (n = 56, 28%). The risk factors that were independently associated with EB CAP were male gender, severe CAP, underweight (body mass index (BMI) < 18.5) and prior extended-spectrum beta-lactamase (ESBL) infection. Additionally, prior ESBL infection, being underweight, cardiovascular diseases and hospitalization in the last 12 months were independently associated with MDR-EB CAP. Conclusion: This study of adults hospitalized with CAP found a prevalence of EB of 6% and MDR-EB of 1.2%, respectively. The presence of specific risk factors, such as prior ESBL infection and being underweight, should raise the clinical suspicion for EB and MDR-EB in patients hospitalized with CAP

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA