Naslov
Chemical Profiles and Anti-inflammatory Activity of the Essential Oils from Seseli gummiferum and Seseli corymbosum subsp. corymbosum

Autori
Tosun, Alev ; Chun, Jaemoo ; Jerković, Igor ; Marijanović, Zvonimir ; Fenu, Maurizio A. ; Aslan, Sena S. ; Tuberoso, Carlo I. G. ; Kim, Yeong S.

Izvornik
Natural Product Communications (1934-578X) 11 (2016), 10; 1523-1526

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Apiaceae, Seseli, Essential oil, COX-2, iNOS, NF-κB

Sažetak
The anti-inflammatory activity of the essential oils from Seseli corymbosum subsp. corymbosum Pall. ex Sm. (SC) and Seseli gummiferum Boiss. & Heldr. subsp. corymbosum (SG) was investigated for the first time on lipopolysaccharide (LPS)- stimulated RAW 264.7 cells. The main constituents (determined by GC-FID and GC-MS analyses) were germacrene D (54.1%) and sabinene (22.4%) in SG oil and β-phellandrene (29.2%), α-phellandrene (8.2%) and germacrene D (2.5%) in SC oil. SC and SG oils inhibited nitric oxide (NO) production with IC50 values of 56.1 and 108.2 μg/mL, respectively. The oils also inhibited prostaglandin E2 (PGE2) with IC50 values of 49.4 μg/mL (SC oil) and 95.5 μg/mL (SG oil). The inhibitory effect of SC and SG oils was accompanied by dose-dependent decreases of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in LPS-induced RAW 264.7 cells. The research of the reporter gene assay on nuclear factor κB (NF-κB) showed that SC and SG oils inhibited NF-κB transcriptional activity. The obtained results suggest that SC and SG oils exert the anti- inflammatory effects in LPS-stimulated RAW 264.7 cells by suppressing NF-κB activation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA