Naslov
Prognostic Significance of Microvascular Injury in Kidney Transplant Recipients

Autori
Vučur, Ksenija ; Knotek, Mladen ; Maksimović, Bojana ; Jureković, Željka ; Bulimbasić, Stela ; Zunec, Renata ; Ljubanović, Danica Galešić

Izvornik
Transplantation (0041-1337) 102 (2018); 465-465

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Transplantation ; rejection ; microvascular injury

Sažetak
Microvascular injury (MVI), characterized by peritubular capilaritis (ptc) and glomerulitis (g) is one of the histopathological features of AMR, although it can be present in T-cell mediated rejection (TCMR), as well. Preexisting donor specific antibody (DSA) and de novo DSA are associated with the development of acute and chronic AMR, leading to increased risk of graft loss. Recent study showed that MVI score ≥2 was associated with increased intragraft expression of DSA-associated transcripts, higher C4d score, and acute and chronic AMR. However, the prognostic significance of MVI on long-term graft outcome in pts receiving active multimodal rejection treatment has not been studied in detail.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA