Naslov
Safety and efficacy evaluation of an isotonic manganese-enriched seawater solution on human nasal epithelium reconstituted in vitro

Autori
De Servi, Barbara ; Meloni, Marisa ; Culig, Josip ; Saaid, Amina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th International Conference on Allergy, Asthma & Clinical Immunology - posters / Journal of allergy & therapy 8(3, Suppl) / - , 2017, 54-54

Skup
11th International Conference on Allergy, Asthma & Clinical Immunology

Mjesto i datum
Edinburgh, Škotska, 07-08.08.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
manganese enriched seawater ; human nasak epithelium ; in vitro

Sažetak
Findings: SAN showed an average TEER of 302 and 323 ohm.cm2 (p<0, 001) on D1 and D4, respectively, safely above tissue integrity limit (100 ohm.cm2). LDH and IL-8 releases were similar for SAN and control at all-time points, also confirming epithelium integrity and safety. SAN showed a significant MCC increase as compared to control (P<0.01). Furthermore, SAN showed faster and greater wound closure than control (86.59% for SAN versus 50.65% at 22 hours). Conclusion: SAN demonstrated efficacy and safety in the in vitro assays. The results support the use of Mn-enriched SAN in relief of rhinitis symptoms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA