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Pregled bibliografske jedinice broj: 1094211

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study

Bancos, Irina; Taylor, Angela E; Chortis, Vasileios; Sitch, Alice J; Jenkinson, Carl; Davidge-Pitts, Caroline J; Lang, Katharina; Tsagarakis, Stylianos; Macech, Magdalena; Riester, Anna et al.
Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study // Lancet diabetes & endocrinology, 8 (2020), 9; 773-781 doi:10.1016/s2213-8587(20)30218-7 (međunarodna recenzija, članak, znanstveni)

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Naslov
Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study

Autori
Bancos, Irina ; Taylor, Angela E ; Chortis, Vasileios ; Sitch, Alice J ; Jenkinson, Carl ; Davidge-Pitts, Caroline J ; Lang, Katharina ; Tsagarakis, Stylianos ; Macech, Magdalena ; Riester, Anna ; Deutschbein, Timo ; Pupovac, Ivana D ; Kienitz, Tina ; Prete, Alessandro ; Papathomas, Thomas G ; Gilligan, Lorna C ; Bancos, Cristian ; Reimondo, Giuseppe ; Haissaguerre, Magalie ; Marina, Ljiljana ; Grytaas, Marianne A ; Sajwani, Ahmed ; Langton, Katharina ; Ivison, Hannah E ; Shackleton, Cedric H L ; Erickson, Dana ; Asia, Miriam ; Palimeri, Sotiria ; Kondracka, Agnieszka ; Spyroglou, Ariadni ; Ronchi, Cristina L ; Simunov, Bojana ; Delivanis, Danae A ; Sutcliffe, Robert P ; Tsirou, Ioanna ; Bednarczuk, Tomasz ; Reincke, Martin ; Burger-Stritt, Stephanie ; Feelders, Richard A ; Canu, Letizia ; Haak, Harm R ; Eisenhofer, Graeme ; Dennedy, M Conall ; Ueland, Grethe A ; Ivovic, Miomira ; Tabarin, Antoine ; Terzolo, Massimo ; Quinkler, Marcus ; Kastelan, Darko ; Fassnacht, Martin ; Beuschlein, Felix ; Ambroziak, Urszula ; Vassiliadi, Dimitra A ; O'Reilly, Michael W ; Young, William F ; Biehl, Michael ; Deeks, Jonathan J ; Arlt, Wiebke ; Glöckner, Stephan ; Sinnott, Richard O. ; Stell, Anthony ; Fragoso, Maria C. ; Kastelan, Darko ; Pupovac, Ivana D. ; Simunov, Bojana ; Cazenave, Sarah ; Haissaguerre, Magalie ; Tabarin, Antoine ; Bertherat, Jérôme ; Libé, Rossella ; Kienitz, Tina ; Quinkler, Marcus ; Langton, Katharina ; Eisenhofer, Graeme ; Beuschlein, Felix ; Brugger, Christina ; Reincke, Martin ; Riester, Anna ; Spyroglou, Ariadni ; Burger-Stritt, Stephanie ; Deutschbein, Timo ; Fassnacht, Martin ; Hahner, Stefanie ; Kroiss, Matthias ; Ronchi, Cristina L. ; Palimeri, Sotiria ; Tsagarakis, Stylianos ; Tsirou, Ioanna ; Vassiliadi, Dimitra A. ; Basile, Vittoria ; Ingargiola, Elisa ; Reimondo, Giuseppe ; Terzolo, Massimo ; Canu, Letizia ; Mannelli, Massimo ; Ettaieb, Hester ; Haak, Harm R. ; Kerkhofs, Thomas M. ; Biehl, Michael ; Feelders, Richard A. ; Hofland, Johannes ; Hofland, Leo J. ; Grytaas, Marianne A. ; Husebye, Eystein S. ; Ueland, Grethe A. ; Ambroziak, Urszula ; Bednarczuk, Tomasz ; Kondracka, Agnieszka ; Macech, Magdalena ; Zawierucha, Malgorzata ; Paiva, Isabel ; Dennedy, M. Conall ; Sajwani, Ahmed ; Sherlock, Mark ; Crowley, Rachel K. ; Ivovic, Miomira ; Marina, Ljiljana ; Deeks, Jonathan J. ; Sitch, Alice J. ; Arlt, Wiebke ; Bancos, Irina ; Chortis, Vasileios ; Giligan, Lorna C. ; Hughes, Beverly A. ; Lang, Katharina ; Ivison, Hannah E. ; Jenkinson, Carl ; Manolopoulos, Konstantinos ; O'Neil, Donna M. ; O'Reilly, Michael W. ; Papathomas, Thomas G. ; Prete, Alessandro ; Shackleton, Cedric H.L. ; Taylor, Angela E. ; Asia, Miriam ; Sutcliffe, Robert P. ; Guest, Peter ; Skordilis, Kassiani ; Bancos, Cristian ; Chang, Alice ; Davidge-Pitts, Caroline J. ; Delivanis, Danae A. ; Erickson, Dana ; Natt, Neena ; Nippoldt, Todd B. ; Thomas, Melinda ; Young Jr., William F.

Izvornik
Lancet diabetes & endocrinology (2213-8587) 8 (2020), 9; 773-781

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adrenal incidentaloma ; steroid metabolomics, adrenocortical carcinoma

Sažetak
Background Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion of adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity of imaging characteristics. We aimed to validate a urine steroid metabolomics approach, using steroid profiling as the diagnostic basis for ACC. Methods We did a prospective multicentre study in adult participants (age ≥18 years) with newly diagnosed adrenal masses. We assessed the accuracy of diagnostic imaging strategies based on maximum tumour diameter (≥4 cm vs <4 cm), imaging characteristics (positive vs negative), and urine steroid metabolomics (low, medium, or high risk of ACC), separately and in combination, using a reference standard of histopathology and follow-up investigations. With respect to imaging characteristics, we also assessed the diagnostic utility of increasing the unenhanced CT tumour attenuation threshold from the recommended 10 Hounsfield units (HU) to 20 HU. Findings Of 2169 participants recruited between Jan 17, 2011, and July 15, 2016, we included 2017 from 14 specialist centres in 11 countries in the final analysis. 98 (4·9%) had histopathologically or clinically and biochemically confirmed ACC. Tumours with diameters of 4 cm or larger were identified in 488 participants (24·2%), including 96 of the 98 with ACC (positive predictive value [PPV] 19·7%, 95% CI 16·2–23·5). For imaging characteristics, increasing the unenhanced CT tumour attenuation threshold to 20 HU from the recommended 10 HU increased specificity for ACC (80·0% [95% CI 77·9–82·0] vs 64·0% [61·4–66.4]) while maintaining sensitivity (99·0% [94·4–100·0] vs 100·0% [96·3– 100·0] ; PPV 19·7%, 16·3–23·5). A urine steroid metabolomics result indicating high risk of ACC had a PPV of 34·6% (95% CI 28·6–41·0). When the three tests were combined, in the order of tumour diameter, positive imaging characteristics, and urine steroid metabolomics, 106 (5·3%) participants had the result maximum tumour diameter of 4 cm or larger, positive imaging characteristics (with the 20 HU cutoff), and urine steroid metabolomics indicating high risk of ACC, for which the PPV was 76·4% (95% CI 67·2–84·1). 70 (3·5%) were classified as being at moderate risk of ACC and 1841 (91·3%) at low risk (negative predictive value 99·7%, 99·4–100·0). Interpretation An unenhanced CT tumour attenuation cutoff of 20 HU should replace that of 10 HU for exclusion of ACC. A triple test strategy of tumour diameter, imaging characteristics, and urine steroid metabolomics improves detection of ACC, which could shorten time to surgery for patients with ACC and help to avoid unnecessary surgery in patients with benign tumours.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Darko Kaštelan (autor)

Avatar Url Bojana Gardijan (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi

Citiraj ovu publikaciju:

Bancos, Irina; Taylor, Angela E; Chortis, Vasileios; Sitch, Alice J; Jenkinson, Carl; Davidge-Pitts, Caroline J; Lang, Katharina; Tsagarakis, Stylianos; Macech, Magdalena; Riester, Anna et al.
Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study // Lancet diabetes & endocrinology, 8 (2020), 9; 773-781 doi:10.1016/s2213-8587(20)30218-7 (međunarodna recenzija, članak, znanstveni)
Bancos, I., Taylor, A., Chortis, V., Sitch, A., Jenkinson, C., Davidge-Pitts, C., Lang, K., Tsagarakis, S., Macech, M. & Riester, A. (2020) Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study. Lancet diabetes & endocrinology, 8 (9), 773-781 doi:10.1016/s2213-8587(20)30218-7.
@article{article, author = {Bancos, Irina and Taylor, Angela E and Chortis, Vasileios and Sitch, Alice J and Jenkinson, Carl and Davidge-Pitts, Caroline J and Lang, Katharina and Tsagarakis, Stylianos and Macech, Magdalena and Riester, Anna and Deutschbein, Timo and Pupovac, Ivana D and Kienitz, Tina and Prete, Alessandro and Papathomas, Thomas G and Gilligan, Lorna C and Bancos, Cristian and Reimondo, Giuseppe and Haissaguerre, Magalie and Marina, Ljiljana and Grytaas, Marianne A and Sajwani, Ahmed and Langton, Katharina and Ivison, Hannah E and Shackleton, Cedric H L and Erickson, Dana and Asia, Miriam and Palimeri, Sotiria and Kondracka, Agnieszka and Spyroglou, Ariadni and Ronchi, Cristina L and Simunov, Bojana and Delivanis, Danae A and Sutcliffe, Robert P and Tsirou, Ioanna and Bednarczuk, Tomasz and Reincke, Martin and Burger-Stritt, Stephanie and Feelders, Richard A and Canu, Letizia and Haak, Harm R and Eisenhofer, Graeme and Dennedy, M Conall and Ueland, Grethe A and Ivovic, Miomira and Tabarin, Antoine and Terzolo, Massimo and Quinkler, Marcus and Kastelan, Darko and Fassnacht, Martin and Beuschlein, Felix and Ambroziak, Urszula and Vassiliadi, Dimitra A and O'Reilly, Michael W and Young, William F and Biehl, Michael and Deeks, Jonathan J and Arlt, Wiebke and Gl\"{o}ckner, Stephan and Sinnott, Richard O. and Stell, Anthony and Fragoso, Maria C. and Kastelan, Darko and Pupovac, Ivana D. and Simunov, Bojana and Cazenave, Sarah and Haissaguerre, Magalie and Tabarin, Antoine and Bertherat, J\'{e}r\^{o}me and Lib\'{e}, Rossella and Kienitz, Tina and Quinkler, Marcus and Langton, Katharina and Eisenhofer, Graeme and Beuschlein, Felix and Brugger, Christina and Reincke, Martin and Riester, Anna and Spyroglou, Ariadni and Burger-Stritt, Stephanie and Deutschbein, Timo and Fassnacht, Martin and Hahner, Stefanie and Kroiss, Matthias and Ronchi, Cristina L. and Palimeri, Sotiria and Tsagarakis, Stylianos and Tsirou, Ioanna and Vassiliadi, Dimitra A. and Basile, Vittoria and Ingargiola, Elisa and Reimondo, Giuseppe and Terzolo, Massimo and Canu, Letizia and Mannelli, Massimo and Ettaieb, Hester and Haak, Harm R. and Kerkhofs, Thomas M. and Biehl, Michael and Feelders, Richard A. and Hofland, Johannes and Hofland, Leo J. and Grytaas, Marianne A. and Husebye, Eystein S. and Ueland, Grethe A. and Ambroziak, Urszula and Bednarczuk, Tomasz and Kondracka, Agnieszka and Macech, Magdalena and Zawierucha, Malgorzata and Paiva, Isabel and Dennedy, M. Conall and Sajwani, Ahmed and Sherlock, Mark and Crowley, Rachel K. and Ivovic, Miomira and Marina, Ljiljana and Deeks, Jonathan J. and Sitch, Alice J. and Arlt, Wiebke and Bancos, Irina and Chortis, Vasileios and Giligan, Lorna C. and Hughes, Beverly A. and Lang, Katharina and Ivison, Hannah E. and Jenkinson, Carl and Manolopoulos, Konstantinos and O'Neil, Donna M. and O'Reilly, Michael W. and Papathomas, Thomas G. and Prete, Alessandro and Shackleton, Cedric H.L. and Taylor, Angela E. and Asia, Miriam and Sutcliffe, Robert P. and Guest, Peter and Skordilis, Kassiani and Bancos, Cristian and Chang, Alice and Davidge-Pitts, Caroline J. and Delivanis, Danae A. and Erickson, Dana and Natt, Neena and Nippoldt, Todd B. and Thomas, Melinda and Young Jr., William F.}, year = {2020}, pages = {773-781}, DOI = {10.1016/s2213-8587(20)30218-7}, keywords = {adrenal incidentaloma, steroid metabolomics, adrenocortical carcinoma}, journal = {Lancet diabetes and endocrinology}, doi = {10.1016/s2213-8587(20)30218-7}, volume = {8}, number = {9}, issn = {2213-8587}, title = {Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study}, keyword = {adrenal incidentaloma, steroid metabolomics, adrenocortical carcinoma} }
@article{article, author = {Bancos, Irina and Taylor, Angela E and Chortis, Vasileios and Sitch, Alice J and Jenkinson, Carl and Davidge-Pitts, Caroline J and Lang, Katharina and Tsagarakis, Stylianos and Macech, Magdalena and Riester, Anna and Deutschbein, Timo and Pupovac, Ivana D and Kienitz, Tina and Prete, Alessandro and Papathomas, Thomas G and Gilligan, Lorna C and Bancos, Cristian and Reimondo, Giuseppe and Haissaguerre, Magalie and Marina, Ljiljana and Grytaas, Marianne A and Sajwani, Ahmed and Langton, Katharina and Ivison, Hannah E and Shackleton, Cedric H L and Erickson, Dana and Asia, Miriam and Palimeri, Sotiria and Kondracka, Agnieszka and Spyroglou, Ariadni and Ronchi, Cristina L and Simunov, Bojana and Delivanis, Danae A and Sutcliffe, Robert P and Tsirou, Ioanna and Bednarczuk, Tomasz and Reincke, Martin and Burger-Stritt, Stephanie and Feelders, Richard A and Canu, Letizia and Haak, Harm R and Eisenhofer, Graeme and Dennedy, M Conall and Ueland, Grethe A and Ivovic, Miomira and Tabarin, Antoine and Terzolo, Massimo and Quinkler, Marcus and Kastelan, Darko and Fassnacht, Martin and Beuschlein, Felix and Ambroziak, Urszula and Vassiliadi, Dimitra A and O'Reilly, Michael W and Young, William F and Biehl, Michael and Deeks, Jonathan J and Arlt, Wiebke and Gl\"{o}ckner, Stephan and Sinnott, Richard O. and Stell, Anthony and Fragoso, Maria C. and Kastelan, Darko and Pupovac, Ivana D. and Simunov, Bojana and Cazenave, Sarah and Haissaguerre, Magalie and Tabarin, Antoine and Bertherat, J\'{e}r\^{o}me and Lib\'{e}, Rossella and Kienitz, Tina and Quinkler, Marcus and Langton, Katharina and Eisenhofer, Graeme and Beuschlein, Felix and Brugger, Christina and Reincke, Martin and Riester, Anna and Spyroglou, Ariadni and Burger-Stritt, Stephanie and Deutschbein, Timo and Fassnacht, Martin and Hahner, Stefanie and Kroiss, Matthias and Ronchi, Cristina L. and Palimeri, Sotiria and Tsagarakis, Stylianos and Tsirou, Ioanna and Vassiliadi, Dimitra A. and Basile, Vittoria and Ingargiola, Elisa and Reimondo, Giuseppe and Terzolo, Massimo and Canu, Letizia and Mannelli, Massimo and Ettaieb, Hester and Haak, Harm R. and Kerkhofs, Thomas M. and Biehl, Michael and Feelders, Richard A. and Hofland, Johannes and Hofland, Leo J. and Grytaas, Marianne A. and Husebye, Eystein S. and Ueland, Grethe A. and Ambroziak, Urszula and Bednarczuk, Tomasz and Kondracka, Agnieszka and Macech, Magdalena and Zawierucha, Malgorzata and Paiva, Isabel and Dennedy, M. Conall and Sajwani, Ahmed and Sherlock, Mark and Crowley, Rachel K. and Ivovic, Miomira and Marina, Ljiljana and Deeks, Jonathan J. and Sitch, Alice J. and Arlt, Wiebke and Bancos, Irina and Chortis, Vasileios and Giligan, Lorna C. and Hughes, Beverly A. and Lang, Katharina and Ivison, Hannah E. and Jenkinson, Carl and Manolopoulos, Konstantinos and O'Neil, Donna M. and O'Reilly, Michael W. and Papathomas, Thomas G. and Prete, Alessandro and Shackleton, Cedric H.L. and Taylor, Angela E. and Asia, Miriam and Sutcliffe, Robert P. and Guest, Peter and Skordilis, Kassiani and Bancos, Cristian and Chang, Alice and Davidge-Pitts, Caroline J. and Delivanis, Danae A. and Erickson, Dana and Natt, Neena and Nippoldt, Todd B. and Thomas, Melinda and Young Jr., William F.}, year = {2020}, pages = {773-781}, DOI = {10.1016/s2213-8587(20)30218-7}, keywords = {adrenal incidentaloma, steroid metabolomics, adrenocortical carcinoma}, journal = {Lancet diabetes and endocrinology}, doi = {10.1016/s2213-8587(20)30218-7}, volume = {8}, number = {9}, issn = {2213-8587}, title = {Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE- ACT study: a prospective test validation study}, keyword = {adrenal incidentaloma, steroid metabolomics, adrenocortical carcinoma} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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