Naslov
A case of an unusual lineage switch in late relapse ALL—is it actually a secondary leukemia?

Autori
Babić, Antonija ; Kurić, Lejla ; Dubravčić, Klara ; Perić, Zinaida ; Batinić, Josip ; Armanda, Višnja ; Kuljiš, Dubravka ; Batinić, Drago

Izvornik
Journal of hematopathology (1868-9256) 13 (2019), 1; 51-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute lymphoblastic leukemia ; Secondary leukemia ; Lineage switch

Sažetak
Acute lymphoblastic leukemia (ALL) is a malignant disease of lymphoid precursors. According to immunophenotype, it is further subdivided into precursor B cell ALL and precursor T cell ALL, with precursor B cell ALL being much more common both in children and adults. Lineage switch from one lymphoid lineage to another during the course of the disease is extremely rarely reported. Here, we describe a case of a child who initially presented as a precursor B-ALL but 15 years later and after two successfully treated relapses of the original ALL presented with early T cell precursor leukemia. Although it was considered as a relapse, it could be interpreted as a case of secondary leukemia, which can be explained as a consequence of treatment as well as a constitutional feature of an individual. Also, it draws attention to the possibility that hematopoietic cells, and in that context also leukemic cells, are much more plastic and capable of reprogramming than previously thought.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA