Pregled bibliografske jedinice broj: 1093304
Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism
Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism // Nature Microbiology, 5 (2019), 2; 331-342 doi:10.1038/s41564-019-0624-1 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1093304 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Herpesviruses induce aggregation and selective
autophagy of host signalling proteins NEMO and
RIPK1 as an immune-evasion mechanism
Autori
Muscolino, Elena ; Schmitz, Rebekka ; Loroch, Stefan ; Caragliano, Enrico ; Schneider, Carola ; Rizzato, Matteo ; Kim, Young-Hyun ; Krause, Eva ; Juranić Lisnić, Vanda ; Sickmann, Albert ; Reimer, Rudolph ; Ostermann, Eleonore ; Brune, Wolfram
Izvornik
Nature Microbiology (2058-5276) 5
(2019), 2;
331-342
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
herpesvirus, NEMO, apoptosis, autophagy
Sažetak
Viruses manipulate cellular signalling by inducing the degradation of crucial signal transducers, usually via the ubiquitin-proteasome pathway. Here, we show that the murine cytomegalovirus (Murid herpesvirus 1) M45 protein induces the degradation of two cellular signalling proteins, the nuclear factor κ-light- chain-enhancer of activated B cells (NF-κB) essential modulator (NEMO) and the receptor- interacting protein kinase 1 (RIPK1), via a different mechanism: it induces their sequestration as insoluble protein aggregates and subsequently facilitates their degradation by autophagy. Aggregation of target proteins requires a distinct sequence motif in M45, which we termed 'induced protein aggregation motif'. In a second step, M45 recruits the retromer component vacuolar protein sorting 26B (VPS26B) and the microtubule-associated protein light chain 3 (LC3)-interacting adaptor protein TBC1D5 to facilitate degradation of aggregates by selective autophagy. The induced protein aggregation motif is conserved in M45-homologous proteins of several human herpesviruses, including herpes simplex virus, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, but is only partially conserved in the human cytomegalovirus UL45 protein. We further show that the HSV-1 ICP6 protein induces RIPK1 aggregation and degradation in a similar fashion to M45. These data suggest that induced protein aggregation combined with selective autophagy of aggregates (aggrephagy) represents a conserved viral immune- evasion mechanism.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
