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Pregled bibliografske jedinice broj: 1092376

ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers

Kirschberg, Matthias; Heuser, Sandra; Marcuzzi, Gian Paolo; Hufbauer, Martin; Seeger, Jens Michael; Đukić, Anamaria; Tomaić, Vjekoslav; Majewski, Slawomir; Wagner, Steffen; Wittekindt, Claus et al.
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers // Scientific reports, 10 (2020), 1; 17339, 12 doi:10.1038/s41598-020-74311-6 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1092376 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers

Autori
Kirschberg, Matthias ; Heuser, Sandra ; Marcuzzi, Gian Paolo ; Hufbauer, Martin ; Seeger, Jens Michael ; Đukić, Anamaria ; Tomaić, Vjekoslav ; Majewski, Slawomir ; Wagner, Steffen ; Wittekindt, Claus ; Würdemann, Nora ; Klussmann, Jens Peter ; Quaas, Alexander ; Kashkar, Hamid ; Akgül, Baki

Izvornik
Scientific reports (2045-2322) 10 (2020), 1; 17339, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human papillomaviruses (HPV), cell metabolism, mitochondrial ATP-synthase (ATP5B), HPV-mediated tumorigenesis

Sažetak
Mucosal and skin cancers are associated with infections by human papillomaviruses (HPV). The manner how viral oncoproteins hijack the host cell metabolism to meet their own energy demands and how this may contribute to tumorigenesis is poorly understood. We now show that the HPV oncoprotein E7 of HPV8, HPV11 and HPV16 directly interact with the beta subunit of the mitochondrial ATP-synthase (ATP5B), which may therefore represent a conserved feature across different HPV genera. By measuring both glycolytic and mitochondrial activity we observed that the association of E7 with ATP5B was accompanied by reduction of glycolytic activity. Interestingly, there was a drastic increase in spare mitochondrial respiratory capacity in HPV8-E7 and an even more profound increase in HPV16-E7 expressing cells. In addition, we could show that ATP5B levels were unchanged in betaHPV positive skin cancers. However, comparing HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas (OPSCC) we noticed that, while ATP5B expression levels did not correlate with patient overall survival in HPV-negative OPSCC, there was a strong correlation within the HPV16-positive OPSCC patient group. These novel findings provide evidence that HPV targets the host cell energy metabolism important for viral life cycle and HPV-mediated tumorigenesis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
HRZZ-IP-2016-06-2246 - Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima (HPVHNC) (Tomaić, Vjekoslav, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Anamaria Đukić (autor)

Avatar Url Vjekoslav Tomaić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.nature.com www.ncbi.nlm.nih.gov doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Kirschberg, Matthias; Heuser, Sandra; Marcuzzi, Gian Paolo; Hufbauer, Martin; Seeger, Jens Michael; Đukić, Anamaria; Tomaić, Vjekoslav; Majewski, Slawomir; Wagner, Steffen; Wittekindt, Claus et al.
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers // Scientific reports, 10 (2020), 1; 17339, 12 doi:10.1038/s41598-020-74311-6 (međunarodna recenzija, članak, znanstveni)
Kirschberg, M., Heuser, S., Marcuzzi, G., Hufbauer, M., Seeger, J., Đukić, A., Tomaić, V., Majewski, S., Wagner, S. & Wittekindt, C. (2020) ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers. Scientific reports, 10 (1), 17339, 12 doi:10.1038/s41598-020-74311-6.
@article{article, author = {Kirschberg, Matthias and Heuser, Sandra and Marcuzzi, Gian Paolo and Hufbauer, Martin and Seeger, Jens Michael and \DJuki\'{c}, Anamaria and Tomai\'{c}, Vjekoslav and Majewski, Slawomir and Wagner, Steffen and Wittekindt, Claus and W\"{u}rdemann, Nora and Klussmann, Jens Peter and Quaas, Alexander and Kashkar, Hamid and Akg\"{u}l, Baki}, year = {2020}, pages = {12}, DOI = {10.1038/s41598-020-74311-6}, chapter = {17339}, keywords = {human papillomaviruses (HPV), cell metabolism, mitochondrial ATP-synthase (ATP5B), HPV-mediated tumorigenesis}, journal = {Scientific reports}, doi = {10.1038/s41598-020-74311-6}, volume = {10}, number = {1}, issn = {2045-2322}, title = {ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers}, keyword = {human papillomaviruses (HPV), cell metabolism, mitochondrial ATP-synthase (ATP5B), HPV-mediated tumorigenesis}, chapternumber = {17339} }
@article{article, author = {Kirschberg, Matthias and Heuser, Sandra and Marcuzzi, Gian Paolo and Hufbauer, Martin and Seeger, Jens Michael and \DJuki\'{c}, Anamaria and Tomai\'{c}, Vjekoslav and Majewski, Slawomir and Wagner, Steffen and Wittekindt, Claus and W\"{u}rdemann, Nora and Klussmann, Jens Peter and Quaas, Alexander and Kashkar, Hamid and Akg\"{u}l, Baki}, year = {2020}, pages = {12}, DOI = {10.1038/s41598-020-74311-6}, chapter = {17339}, keywords = {human papillomaviruses (HPV), cell metabolism, mitochondrial ATP-synthase (ATP5B), HPV-mediated tumorigenesis}, journal = {Scientific reports}, doi = {10.1038/s41598-020-74311-6}, volume = {10}, number = {1}, issn = {2045-2322}, title = {ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers}, keyword = {human papillomaviruses (HPV), cell metabolism, mitochondrial ATP-synthase (ATP5B), HPV-mediated tumorigenesis}, chapternumber = {17339} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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