Naslov
Difference in presence and number of CD83+ dendritic cells in patients with ulcerative colitis and Crohn’s disease

Autori
Rošić Despalatović, Bruna ; Babić, Marija ; Bratanić, Andre ; Tonkić, Ante ; Vilović, Katarina

Izvornik
Scientific reports (2045-2322) 10 (2020); 10055, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD83+ dendritic cell ; ulcerative colitis ; Crohn's disease

Sažetak
Different pathophysiological models provide insight into the important role of CD83+ dendritic cells (DCs) in the pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC). There were 154 subjects included in this study: 60 with UC, 19 with CD and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody. Intraepithelial DCs per 100 enterocytes were counted. The results were analysed according to demographic data, type of IBD and histological inflammation pattern. The odds ratio for CD83+ DCs=0 in the UC group was 3.4 times higher than that in the control group (OR = 3.4 ; 95% CI: 1.63–7.14 ; p = 0.001), and the odds ratio for CD83+ DCs ≥1 in the CD group was 5.3 times higher than that in the UC group (OR = 5.3 ; 95% CI: 1.4–20.2 ; p = 0.014). The odds ratio for CD83+ DCs=0 in the acute inflammation group was 2.7 times higher than that in the group without inflammation (OR = 2.7 ; 95% CI: 1.2–5.9 ; p = 0.011). In the group of patients with CD and acute inflammation (n = 11), there was only one subject without CD83+ DCs (p = 0, 024). These results suggest an association of CD83+ DCs with the type of IBD and the histological inflammation pattern.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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