Naslov
Renal function is associated with development of cataract in patients with type 2 diabetes

Autori
Tomić, Martina ; Vrabec, Romano ; Ljubić, Spomenka ; Bulum, Tomislav ; Prkačin, Ingrid ; Rahelić, Dario

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka 9. Hrvatskog kongresa nefrologije, dijalize i transplantacije s međunarodnim sudjelovanjem / Laganović M, Bubić I - Zagreb : Hrvatski liječnički zbor ; Hrvatsko društvo za nefrologiju, dijalizu i transplantaciju, 2020, 65-65

Skup
9. Hrvatski kongres nefrologije, dijalize i transplantacije s međunarodnim sudjelovanjem

Mjesto i datum
Online, 22.10.2020. - 24.10.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
renal function, cataract, type 2 diabetes

Sažetak
This was a cross-sectional study including 107 type 2 diabetic patients (67 male/40 female, mean age 66.74 ± 8.01 years, mean diabetes duration 15.05 ± 5.69 years). Metabolic risk factors: glycated hemoglobin (HbA1c), total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were determined using routine laboratory methods. Renal function was etermined using albumin/creatinine (A/C) ratio and estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI formula. Lens opacity was graded according to the Lens Opacity Classification System version III (LOCSIII). RESULTS AND CONCLUSION Patients were divided into three groups: group 1 - patients with clear crystalline lens (n=16), group 2 - patients with initial cataract (n=74), and group 3 - patients with immature cataract (n=17). Group 3 had significantly longer diabetes duration (17.12 ± 6.38 years vs. 10.81 ± 4.09 years ; p<0.001) and marginally higher HbA1c (7.11 ± 1.06% vs. 6.38 ± 0.82% ; p=0.052) than group 1. Diabetic retinopathy (DR) was significantly more severe (35/29/36% vs. 82/6/12% ; p=0.047) and eGFR significantly lower (53 ± 18 mlmin-11.73m-2 vs. 72 ± 12 mlmin-11.73m-2 ; p=0.017) in group 3 than in group 1. Cataract was positively correlated with diastolic blood pressure (p=0.002), DR (p=0.009) and A/C ratio (p=0.004). Multiple logistic regression analysis showed that the influence of diastolic blood pressure (AOR=1.06, 95%CI 1.00-1.12, p=0.039) and eGFR (AOR=3.02, 95%CI 1.07-8.49, p=0.034) on cataract development remained significant even after adjustment for diabetes duration and HbA1c. Conclusion: This study showed that renal function determined using A/C ratio and eGFR along diabetes duration, hemoglobin A1c, and blood pressure play an important role in the cataract development in type 2 diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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