Naslov
Association between homocysteine and the risk of retinopathy in type 2 diabetes

Autori
Tomić, Martina ; Vrabec, Romano ; Vidas Pauk, Sania ; Ljubić, Spomenka ; Bulum, Tomislav ; Rahelić, Dario

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Ophthalmology, Vol. 30, No. 1 (2020) / - Thousand Oaks (CA) : SAGE Publishing, 2020, 16-17

Skup
30th Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec)

Mjesto i datum
Barcelona, Španjolska; online, 05.11.2020. - 06.11.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
homocysteine ; retinopathy, type 2 diabetes
(homocysteine, retinopathy, type 2 diabetes)

Sažetak
PURPOSE. To assess the role of homocysteine in development of diabetic retinopathy in patients with type 2 diabetes and determine the parameters important in the prediction of homocysteine. METHODS. This cross-sectional study included 94 type 2 diabetic patients (39M/55F) with median age 60 years and median diabetes duration 10 years. Glycated hemoglobin (HbA1c), fasting blood glucose (fBG), fasting C-peptide, HDL and LDL cholesterol, triglycerides (TG)and uric acid (UA) were determined using routine laboratory methods. Glomerular filtration rate (GFR) was estimated using CKD-EPI formula. Homocysteine (HCY) in EDTA plasma, serum 25- hydroxy-vitamin D, vitamin B12 and folate were determined by CMIA method. Anthropometric parameters assessed waist circumference (WC) and waist-to-hip ratio (WHR). Ophthalmologic examination included fundus photography according to the EURODIAB methodology and optical coherence tomography of the macula. Patients with PDR and DME were not included in the study. RESULTS. Patients were divided into two groups: group 1 (no retinopathy ; n=69) and group 2 (NPDR ; n=25). The groups did not differ in age, gender, WC, WHR, fBG, C-peptide, HDL, LDL, TG, UA, folate and vitamin D. Group 2 had longer diabetes duration (p<0.001), marginally higher HbA1c (p=0, 059), higher HCY (p<0.001), lower B12 (p=0.028) and lower GFR (p=0.004) than group 1. DR was positively associated with diabetes duration (p<0.001), HbA1c (p=0.049) and HCY (p<0.001), and negatively with B12 (p=0.027) and GFR (p=0.005). Logistic regression analyses showed that diabetes duration (OR=1.13, p<0.001), HCY (OR=1.06, p=0.047) and GFR (OR=0.96, p=0.004) were the main predictors of DR in type 2 diabetic patients. However, after adjustment for diabetes duration, HbA1c (OR=1.41, p=0.043) also showed increased risk for DR in these patients. The best model for predicting HCY (R2=0.104) obtained from stepwise regression included vitamins B12 and D. CONCLUSIONS. Higher serum homocysteine is associated with diabetic retinopathy and may play a role as a risk factor for its evelopment in type 2 diabetes. Vitamins B12 and D seem to modify this association. Further studies are needed to validate these bservations and investigate possible role of vitamins B12 and D supplementation in the prevention of retinopathy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA