Naslov
Additional methodological considerations regarding optimization of the dose of intracerebroventricular streptozotocin A response to: “Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats” by Ghosh et al., Metab Brain Dis 2020 July 21

Autori
Homolak, Jan ; Babić Perhoč, Ana ; Knezović, Ana ; Osmanović Barilar, Jelena ; Šalković-Petrišić, Melita

Izvornik
Metabolic brain disease (0885-7490) 36 (2020), 6; 97-102

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, komentar, ostalo

Ključne riječi
intracerebroventricular ; streptozotocin

Sažetak
A recent article by Ghosh et al. entitled "Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats" provides an important new set of information on neuroinflammation and cognitive deficit in a rat model of sporadic Alzheimer's disease (sAD) based on intracerebroventricular administration of streptozotocin (STZ-icv) in Charles-Foster rats in the early post-treatment period of 21 days. This comment is supposed to supplement the aforementioned manuscript by providing additional perspective on important factors that should be taken into account in the process of optimization of the streptozotocin (STZ) dose for intracerebroventricular treatment, and provides a brief overview of possible sources of variation of experimental results reported by different groups working with STZ-icv rodent models.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA