Naslov
Effect of betahistine on tinnitus and vertigo in cerebrovascular patients

Autori
Runjić, Nađa ; Kramarić, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
45th International Neuropsychiatric Congress: abstract book / - , 2004

Skup
45th International Neuropsychiatric Congress

Mjesto i datum
Pula, Hrvatska, 15.06.2005. - 18.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
tinnitus ; cerebrovascular disease ; betahistine

Sažetak
The aim of this study was to investigate the effect of betahistine dihydrochloride (Betaserc) on the tinnitus and vertigo in cerebrovascular patients. Patients and methods: Twenty persons with the cochlear tinnitus and central vestibular vertigo, ages 30-60 years (mean age 48, 70 years) were tested. The control group consisted of 15 patients matched by the age, gender, cerebrovascular status, audiological and vestibular findings (mean age 45, 60 years. The complete otoneurological diagnostics, including doppler flow imaging and electronystagmography was performed before and after the therapy. After the diagnostic evaluation subjects were treated by peroral Betaserc administrated 16 mg three times daily for eight weeks. Ten patients were also included in the functional therapy of tinnitus according to the verbotonal method of Petar Guberina using the SUVAG apparatus for masking the tinnitus. Data were analyzed by ANOVA statistics. The average period of dizziness duration before the diagnostics evaluation is 3, 2 months (5 days-2 years), for tinnitus 8 months (1 month-3 years). The leading risk factors for celebrovascular disease, hypertension, diabetes and hyperlipidaemia were found in all 35 patients (hypertension in 5 patients, diabetes in 3 patients, hyperlipidaemia in 7 patients, hypertension + hyperlipidaemia in 11, all thre factors in 4 patients). After Betaserc treatment, the severity of dizziness and occurence of nausea were significantly reduced (p=0.005 ; p=0.001). In the electronystagmographic evaluation pathologivcal visuo-oculomotor reactions and pathological cervical test result disapeared in 14 of 20 patients, smooth pursuit improved in 16 atients, and cervical nystagmus disapeared in 14 patients. Tinnitus disapeared in only 6 patients, those included in the functional therapy of tinnitus, with "diagnostic window" of 2 months. The results indicate Betaserce as an effective therapy in patients with central vestibular vertigo. The tinnitus patients need complex diagnostic and therapeutic approach, with an appropriate time of the diagnostic and therapeutic intervention, within 2 months of tinnitus onset.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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