Naslov
Paediatric infective endocarditis: case series

Autori
Krajcar, Nina ; Stemberger Marić, Lorna ; Roglić, Srđan ; Barušić, Zoran ; Tešović, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Skup
29th ECCMID 2019

Mjesto i datum
Amsterdam, Nizozemska, 13.04.2019. - 16.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Congenital heart disease ; infective endocarditis ; children

Sažetak
Background: Congenital heart disease (CHD) is the predominant underlying condition for infective endocarditis (IE) in children. Increasingly, IE develops in the absence of CHD, mostly in patients with central venous catheters. In 8 to 10% of all cases there is no identifiable risk factor. Materials/methods: A total of 11 cases of IE in patients younger than 18 years of age were treated in University Hospital for Infectious Diseases in Zagreb in the past 14 years (2005- 2018). Clinical manifestations, causative pathogens and treatment outcome were retrospectively analysed using medical records. Results: There were 7 boys and 4 girls, aged 7 months to 17 years (median 7 years). 55% of cases were caused by usually isolated bacteria (2 Coagulase-negative Staphylococcus, 2 Staphylococcus aureus, 1 Streptococcus sanguinis, 1 Streptococcus gordonii), while almost half of them (45%) were caused by relatively uncommon organisms in pediatric population: Enterococcus faecalis (n=2), Granulicatella adiacens (n=1), Haemophilus parainfluenzae (n=1) and Abiotrophia defectiva (n=1). Although one patient (9%) didn´t have risk factor for IE, all of the others had CHD and one of them had central venous catheter as well. Septic embolisation was present in 2 patients: meningoencephalitis in a patient with S. aureus IE and pulmonary involvement in a case with S. gordonii IE. Two patients had relapse of IE (caused by CoNS and Staphylococcus aureus). The most frequent antibiotic regimen for first 2 weeks of therapy was penicillin or its derivatives combined with gentamicin. Total duration of treatment was 6-8 weeks. Mortality rate was 18%, while others recovered completely. Conclusions: IE is a rare bacterial infection usually affecting children with CHD. Although IE is uncommon in children without risk factors, it should be suspected in patients with nonspecific clinical symptoms. In our case series Staphylococcus spp predominated as causative microorganism. We also noticed high proportion of cases caused by unusual bacteria and relatively low prevalence of streptococcal IE.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA