Naslov
The role of cellular immunity in primary campylobacteriosis

Autori
Vučković, Darinka ; Dorić, Miljenko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Makedonski medicinski pregled : Book of abstracts / Panovski, Nikola - : Macedonian Microbiological Society, 1997, 92-92

Skup
1st Congress of the Macedonian Microbiologists with International Participation

Mjesto i datum
Ohrid, Sjeverna Makedonija, 14.05.1997. - 17.05.1997

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
campylobacteriosis; pathogenesis

Sažetak
After establishing an experimental model of primary campylobacteriosis in C57Bl/6 mice, we were able to follow up the infection in the livers and spleens of these animals. Primary infection resulted in hepatosplenomegaly, as well as, in evident pathohistological changes of these tissues. Animals with depleted CD4+, CD8+ or NK cells were regularly capable of completely eliminating C. jejuni from analysed organs during the primary infection. Duration of primary infection in livers of CD4+, CD8+ depleted mice was prolonged and the number of CFU was increased. In NK depleted animals the munber of CFU in the liver was even more increased. Primary infection in the spleen was very much prolonged in CD8+ and NK depletion mice. The results show that cellular immunity indeed plays an important role in the defence against this bacteria and must be taken into account.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA