Naslov
The effect of triamterene upon the rat kidney plasma membrane Na-K-ATP-ase activity

Autori
Ožegović, Božena ; Schön, Elizabeta ; Milković, Stevan

Izvornik
Archives Internationales de Pharmacodynamie et de Therapie (0003-9780) 241 (1979), 1; 16-23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
triamterene; Na-K-ATP-ase

Sažetak
Triamterene (2, 4, 7-triamino-6-phenylptridine) is a potassium-sparing diuretic whose mechanism of action is not clear. Experiments were performed to study the effect of triamterene upon the activity of Na-K-ATP-ase in the kidney plasma membranes. This enzyme, dissolved within the membrane bilayer, has been cinsidered to be a biochemical vehicle for the active transport of sodium across the cell membrane. Intact and adrenalectomized rats were subjected to a five-day treatment with triamterene in a daily dose of 1, 5 mg/100 g body weight. Triamterene was also administered to a group of intact, salt-loaded, rats. The activity of Na-K-ATP-ase in the kidney plasma membranes of intact and adrenalectomized rats treated with triamterene was decreased by 22, 4% (p<0, 05) and 37, 2% (p<0, 05), respectively. The activity of Na-K-ATP-ase in the renal plasma membranes of intact, salt-loaded, rats underwent greater decrease - 63% (p<0, 05). If the decreased activity of Na-K-ATP-ase in the kidney plasma membranes of rats treated with triamterene manifested the diuretic action of triamterene, results obtained in adrenalectomized rats would suggest that triamterene acts directly on the kidney, not via the adrenal glands.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA