Naslov
RISK OF SARCOPENIA IN RHEUMATOID ARTHRITIS PATIENTS

Autori
Vlak, Tonko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2018)

Mjesto i datum
Kraków, Poljska, 19.04.2018. - 22.04.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Rheumatic Arthritis ; Sarcopenia

Sažetak
Objective:Rheumatoid arthritis is most frequently associatedwith development of sarcopenia among chronic inflammatorydisease group. Risk of adverse outcomes, such as physicaldisability, poor quality of life and higher mortality rates, inrheumatoid arthritis is increasing with the development ofsarcopenia. Therefore, we performed systematic literaturesearch to provide closer look in causal factors and risks fordevelopment of sarcopenia.Methods:A systematic literature search was carried out inMEDLINE ; Cochrane Library, PEDro and ACR/EULARmeeting abstracts.Results:Although the exact mechanisms for sarcopenia de-velopment in rheumatoid arthritis still remains to be elucidat-ed, several factor have been proposed such as increased pro-duction of pro-inflammatory cytokines, mainly tumor necrosisfactor-alpha and interleukin-1 beta, hormonal changes, oxida-tive damage, reduced protein synthesis in myocytes, insulinresistance, inadequate protein ingestion, physical activity lim-itation and pain. Furthermore, it is shown that somereumathoid arthritis associated disease and treatment charac-teristics can also contribute to development of sarcopenia suchas: increasing joint deformity, self-reported disability scores, C-reactive protein levels, rheumatoid factor seropositivity, anda lack of current treatment with disease-modifying antirheu-matic drugs. Sex and age differences should also be taken in toaccount when considering body composition phenotypes ofrheumatoid arthritis. The good news is that most of abovementioned factors could be alleviated but in order to start withthe treatment of sarcopenia we have to be aware of high prev-alence of sarcopenia among rheumatoid arthritis patients andimprove clinical detection tools.Conclusion:Risk of sarcopenia development in rheumatoidarthritis is rather high and can have devastating consequenceson quality of life, morbidity and mortality. In the managementS146Osteoporos Int (2018) 29 (Suppl 1):S109–S147 of rheumatoid arthritis patients, we should consider preven-tion and treatment of sarcopenia as one of main strategies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA