Naslov
Fumonisins and their effects on animal health - a brief review

Autori
Šegvić, Maja ; Pepeljnjak, Stjepan

Izvornik
Veterinarski arhiv (0372-5480) 71 (2001), 5; 299-323

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, stručni

Ključne riječi
fumonisins ; Fusarium moniliforme ; animal toxicosis ; ceramide synthase ; phospholipids

Sažetak
Fumonisins are mycotoxins produced by certain Fusarium moulds, principally Fusarium moniliforme a worldwide corn contaminant. It is already well known that fumonisins are associated with various animal toxicosis and carcinomas including leukoenecephalomalacia (ELEM), porcine pulmonary oedema (PPE), hepatotoxicosis, hepatocarcinomas, nephrotoxicosis and immunosuppressive effects. Between fumonisin isomers FB1 is predominant molecular form and major toxicant. It has been found that FB1 disrupt sphingolipide metabolism on many types of cells and tissues trough the inhibition of ceramide synthase, a key enzyme in de novo sphingolipide biosynthesis and reacylation of free sphingosine. The second mechanism of toxicity involves changes in the polyunsaturated fatty acid and disruption of membrane phospholipids. Different toxic effects of FB1 were evaluated in many sorts of animals, like Equidae, swine, rat, mice rabbit, chicken, non-human primates and other. Exposure assessment, legislative and efficient detoxification are needed to be done to avoid unwanted consequences and economical losses.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina

POVEZANOST RADA