Pregled bibliografske jedinice broj: 1082483
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells // 18. Ružičkini dani "Danas znanost – sutra industrija" - knjiga sažetaka / Jukić, Ante (ur.).
Zagreb : Osijek: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2020. str. 25-25 (poster, recenziran, sažetak, znanstveni)
CROSBI ID: 1082483 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Photodynamic activity of amphiphilic tripyridylporphyrins on melanoma cells
Autori
Cindrić, Anamarija ; Penić-Ivanko, Laura ; Mušković, Martina ; Ratkaj, Ivana ; Malatesti, Nela
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
18. Ružičkini dani "Danas znanost – sutra industrija" - knjiga sažetaka
/ Jukić, Ante - Zagreb : Osijek : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2020, 25-25
ISBN
978-953-6894-75-8
Skup
18. Ružičkini dani "Danas znanost - sutra industrija"
Mjesto i datum
Vukovar, Hrvatska, 16.09.2020. - 18.09.2020
Vrsta sudjelovanja
Poster
Vrsta recenzije
Recenziran
Ključne riječi
photodynamic therapy ; amphiphilic porphyrins ; melanoma cell line
Sažetak
Melanomas are difficult to treat due to variety of resistance mechanisms, such as defects in apoptotic pathways, ABC transporters and melanin [1, 2]. Photodynamic therapy (PDT) shows some encouraging results against melanoma, thanks to multitarget mechanism of action [1]. Amphiphilic porphyrins have been widely investigated due to their possibility to pass through membrane, as well as being water soluble. Our research group has previously described activity of pyridylporphyrins on several cell lines, and amphiphilic porphyrins showed significantly higher PDT activity compared to their hydrophilic analogues [4]. Here we study the impact of conjugation of hydrophobic chains of various length within N- methylated and N-oxidised pyridylporphyrins. Physicochemical differences between groups are investigated on singlet oxygen production, stability, spectroscopic properties, and lipophilicity of the photosensitizers (PSs). Photodynamic activity will be evaluated on MEWO melanoma cell line by testing cytotoxicity and localization of the PSs inside cells.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
uniri-prirod-18-173
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
