Naslov
Microbial resistance to macrolide-lincosamide-streptogramin B resistance based on ribosome methylation

Autori
Maravić, Gordana ; Flögel, Mirna

Izvornik
Acta Pharmaceutica (1330-0075) 48 (1998), 1; 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ErmC' methyltransferase; bacterial resistance; Erm family; macrolide-lincosamide-streptogramin B antibiotics

Sažetak
Recent information on bacterial resistance to macrolide-lincosamid-streptogramin type B (MLS) antibiotics has been reviewed and discussed. MLS antibiotics block protein synthesis by inhibiting the ribosome 50S subunit function. The Erm family of methyltransferases is responsible for the development of resistance to the MLS antibiotics. These enzymes methylate specific adenine of 23S ribosomal RNA that prevents the MLS antibiotics from binding to the ribosome and from exhibiting their antibacterial activity. Erm methyltransferases show either constitutive or inducibile mode of synthesis and their expression is regulated entirely at the translational level. Structural features of ErmAM methyltransferase show the catalytic domain similarity and a novel fold of substrate binding domain in comparison to other methyltransferases. This opens up the possibility of designing potent inhibitor that might block the resistance conferring methylation activity of the protein.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA