Naslov
Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia
(Clinical relevance of differentiation between Mycobacterium avium and M. intracellulare in M. avium complex pulmonary disease in Croatia)

Autori
Glodić, Goran ; Sabol, Ivan ; Žmak, Ljiljana ; Šola, Ana Marija ; Marušić, Ante ; Hećimović, Ana ; Džubur, Feđa ; Jakopović, Marko ; Kardum Bulat, Ljiljana ; Pavliša, Gordana ; Samaržija, Miroslav ; Čivljak, Antonija ; Dakić, Antonija ; Janković Makek, Mateja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The European respiratory journal, 54 (2019), Suppl 63 / - , 2019

Skup
29th ERS International congress

Mjesto i datum
Madrid, Španjolska, 28.09.2019. - 02.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
treatments ; bacteria ; orphan diseases

Sažetak
Introduction: Clinical differences between M. avium and M. intracellulare haven't been fully studied. Aims and objectives: to asses the relevance of M. avium complex (MAC) members ; record treatment outcomes and long term survival of MAC pulmonary disease (MAC-PD) patients. Methods: retrospective study on all Croatian residents with MAC respiratory isolates from 2006 to 2016 with follow up to 2018. ATS/IDSA guidelines were used to establish MAC-PD and evaluate treatment adequacy. Results: Medical records were available for 93/149 (62.4%) isolates. MAC-PD was diagnosed in 36/49 73.4%) of M. avium and 24/44 (54.5%) of M. intracellulare isolates. Fibrocavitary form and smear positivity were more common with M. intracellulare than M. avium - 33.3 vs. 22.2% and 61 vs. 27.6%, respectively. Treatment was started in 23/36 (63.9%) of M. avium and 21/23 (91.3%) of M. intracellulare. Adequate regimen was administered in 26.1% (6/23) of M. avium and 55% (11/20) of M.intracellulare patients, and microbiological cure was achieved in 83.3% and 72.7% of cases, respectively. One-year mortality of M. avium patients was 19.4% compared to 8.3% of M. intracellulare. 5-year all-cause mortality amounted to 36% and 30% of M. avium and M. intracellulare cases, respectively (p=0.876). Conclusions: M. avium showed a higher percentage of isolates meeting the MAC-PD criteria. Still, M.intracellulare disease was more severe in its presentation, which partly explains the higher rate and adequacy of treatment. Although one-year mortality of M. avium cases was doubled compared to M. intracellulare, there were no differences in long term survival between the two groups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA