Naslov
Synthesis and binding or permethylated diamondoid ammonium salts

Autori
Alešković, Marija ; Jozepović, Ruža ; Roca, Sunčica ; Bregović, Nikola ; Šekutor, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu, 2020, 37-37

ISBN
978-953-6076-58-1

Skup
4th Adriatic NMR conference 2020

Mjesto i datum
Peroj, Hrvatska; Vodnjan, Hrvatska, 22.09.2020. - 24.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
permethylated diamondoid salts ; synthesis ; inclusion complex ; thermodynamics

Sažetak
Supramolecular complexes are stabilized by non-covalent interactions between the host and the guest molecule. Molecular recognition studies can give insight into many processes occurring in nature and prove useful for technological applications. It was recently demonstrated that functionalized adamantane and diamantane ammonium salts are suitable guests for cucurbituril hosts. Moreover, some diamantane derivatives are capable of extremely tight binding with cucurbiturils in water, forming complexes with attomolar dissociation constants. Such ultrastable complexes rival the strength of binding processes acting in biomolecular receptors (e.g., avidin-biotin). As a continuation of our research, we explored complexation of selected adamantane and diamantane ammonium salts with cyclodextrin host molecules. The binding strength was assessed as a function of diamondoid salt size, functional group position and cyclodextrin cavity size. By changing these parameters, a structure-selectivity relationship can be determined and next generation of guests proposed. Various NMR spectroscopic techniques and ITC measurements were employed to determine the stability constants and explore host-guest interactions. Computation methods were used to gain further insight into structural features of formed complexes and to better understand the factors governing their stabilities.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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