Naslov
Effect of n-3 polyunsaturated fatty acid- enriched chicken eggs consumption in patients with known atherosclerotic coronary artery disease on pro-inflammatory cytokines

Autori
Mihaljević, Zrinka ; Matić, Anita ; Stupin, Ana ; Mihalj, Martina ; Selthofer-Relatić, Kristina ; Kibel, Aleksandar ; Breškić-Ćurić, Željka ; Lukinac, Anamarija ; Kolobarić, Nikolina ; Šušnjara, Petar ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 14th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“ - Abstract Book / - , 2020

Skup
14th Annual Symposium of the Croatian Physiological Society with international participation

Mjesto i datum
Online, 25.09.2020. - 26.09.2020

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytokines ; functional food ; atherosclerosis ; coronary artery disease ; n-3 PUFAs ; inflammation

Sažetak
INTRODUCTION: Chronic inflammation plays a key role in the pathogenesis of atherosclerosis and other cardiovascular diseases. N-6 and n-3 polyunsaturated fatty acids (PUFAs) are precursors of eicosanoids, lipid mediators of inflammation. Eicosanoids from n-6 PUFA (e.g. arachidonic acid) have pro-inflammatory and immunoactive activity, whereas eicosanoids from n-3 PUFA (e.g. eicosapentanoic and dochexanoic acid) have anti-inflammatory properties. AIM: The aim of this study was to determine serum concentrations of inflammatory cytokines and hsCRP in chronic cardiovascular patients of both sexes (ntotal = 19) before and three weeks after consumption of standard eggs (control group, n = 9) or n-3 PUFAs enriched chicken eggs (experimental group, n = 10), and examine their interrelation. MATERIALS AND METHODS: The subjects consumed three boiled eggs daily for three weeks, the total amount of n-3 PUFA per day was 249 mg for the control group, and for the experimental group 1053 mg n-3PUFA / day. The concentrations of inflammatory cytokines IL-1α, IL-10, IL-6, MCP-1 and TNF-α were determined by the ProCarta Multiplex kit on the Luminex device. For group comparisons a t-test was used, while within- group comparisons were performed using paired t-test or Wilcoxon test, statistical significance was set as P <0.05. The study was approved by the Ethics Committee of the Clinical Hospital Center Osijek, and all subjects signed an informed consent. RESULTS: hsCRP was significantly decreased after consumption of n-3 PUFAs enriched eggs, whereas it increased significantly when consuming ordinary eggs. The results show no significant difference in the concentrations of proinflammatory cytokines before and after the consumption of n-3 PUFA enriched eggs or in comparison with the consumption of ordinary eggs. However, there was a difference in the relative change (delta) of IL-1α and hsCRP, which decreased significantly more in the experimental group compared to the control group. Furthermore, IL-1α concentration positively correlated with hsCRP in both groups. CONCLUSION: These results suggest that the consumption of n-3 PUFAs enriched eggs reduces the tendency for inflammation. FUNDING: The study was supported by European Structural and Investment Funds through a grant to the Croatian National Science Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek # KK.01.1.1.01.0010.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA