Naslov
The innate immune toll-like-receptor-2 modulates the depressogenic and anorexiolytic neuroinflammatory response in obstructive sleep apnoea

Autori
Polšek, Dora ; Cash, Diana ; Veronese, Mattia ; Ilić, Katarina ; Wood, Tobias C. ; Milošević, Milan ; Kalanj-Bognar, Svjetlana ; Morrell, Mary J. ; Williams, Steve C. R. ; Gajović, Srećko ; Leschziner, Guy D. ; Mitrečić, Dinko ; Rosenzweig, Ivana

Izvornik
Scientific reports (2045-2322) 10 (2020), 1; 11475, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
neuroscience ; physiology ; medical research ; neurology ; pathogenesis

Sažetak
The increased awareness of obstructive sleep apnoea’s (OSA) links to Alzheimer’s disease and major psychiatric disorders has recently directed an intensifed search for their potential shared mechanisms. We hypothesised that neuroinfammation and the microglial TLR2- system may act as a core process at the intersection of their pathophysiology. Moreover, we postulated that infammatory- response might underlie development of key behavioural and neurostructural changes in OSA. Henceforth, we set out to investigate efects of 3 weeks’ exposure to chronic intermittent hypoxia in mice with or without functional TRL2 (TLR2+/+, C57BL/6-Tyrc-Brd-Tg(Tlr2- luc/gfp)Kri/Gaj ; TLR2−/−, C57BL/6-Tlr2tm1Kir). By utilising multimodal imaging in this established model of OSA, a discernible neuroinfammatory response was demonstrated for the frst time. The septal nuclei and forebrain were shown as the initial key seed-sites of the infammatory cascade that led to wider structural changes in the associated neurocircuitry. Finally, the modulatory role for the functional TLR2-system was suggested in aetiology of depressive, anxious and anorexiolytic symptoms in OSA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA