Naslov
Age and SARS-CoV-2 infection

Autori
Dodig, Slavica ; Čepelak, Ivana ; Pavić, Ivan

Izvornik
Acta medica Croatica (1330-0164) 74 (2020), 2; 135-144

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
age ; angiotensin-converting enzyme 2 (ACE2) ; coronaviruses ; COVID-19 ; SARS-CoV-2

Sažetak
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2), a novel virus of the beta coronavirus group RNA viruses, is responsible for a zoonotic disease named COVID-19 (coronavirus disease from 2019). The main receptor through which the virus enters the host cell is angiotensin-converting enzyme 2 (ACE2), known as a multifunctional protein. ACE2 expression has been found in oral and nasal mucosa, lungs, adipose tissue, heart, brain, kidneys, vascular tissue, stomach, liver. Upon entry of the virus into the target host cells, two processes are initiated, the host's immune response, and the inflammatory cascade. As immune (innate and adaptive) and inflammatory responses change throughout life both qualitatively and quantitatively, both processes are responsible for varying degrees of disease severity depending on the patient’s age. Short-time experience with SARS-CoV-2 infection has shown that: (i) children and adolescents develop the disease with mild symptoms, mainly on upper respiratory airways ; (ii) the disease has a more severe course in adult patients with associated chronic diseases, such as cardiovascular and renal diseases, chronic respiratory diseases, diabetes etc ; (iii) the most severe, often fatal disease occurs in the elderly, due to more pronounced processes of immunosenescence and inflamm-aging.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA