Pregled bibliografske jedinice broj: 1075501
Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer
Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer // Annals of Diagnostic Pathology, 48 (2020), 151596, 8 doi:10.1016/j.anndiagpath.2020.151596 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1075501 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Correlation of folate receptor alpha expression
with clinicopathological parameters and outcome
in triple negative breast cancer
Autori
Zagorac, Irena ; Lončar, Branka ; Dmitrović, Branko ; Kralik, Kristina ; Kovačević, Andrej
Izvornik
Annals of Diagnostic Pathology (1092-9134) 48
(2020);
151596, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Folate receptor alpha ; Triple negative breast cancer ; H-score ; Survival ; Clinicopathological features
Sažetak
Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this study was to examine FRα expression in a cohort of patients with triple negative breast cancer (TNBC), in correlation with clinicopathological parameters and prognostic factors. By using polyclonal FRα antibody on archival paraffin blocks immunohistochemistry was performed. To evaluate the expression of FRα, H-score was used, which marks both the proportion of stained cells and the intensity of staining. Statistical analysis correlating FRα expression with clinicopathologic parameters and clinical outcome were performed. FRα was expressed in most of the patients (85%). Significant correlation of expression and histologic grade (Mann Whitney U test, P = 0, 03) and type of tumor (P = 0, 02), was found. It was noticed that with higher Ki-67 proliferation index values, H-score has lower values (r = −0, 284, P = 0, 006). Multivariant regression analysis (Cox regression, Stepwise method) showed H- score as a significant predictor for the risk of disease recurrence (OR = 1, 005, P = 0, 04). No correlation between FRα expression and overall survival (OS) and disease-free survival (DFS) was found. In conclusion, FRα is highly expressed in TNBC, and, given the correlation with clinicopathological parameters, subpopulation of patients could be identified that could be potential targets for new therapeutic perspectives in the treatment of this breast cancer subtype.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek,
Fakultet za dentalnu medicinu i zdravstvo, Osijek
