Naslov
Dijagnostika i liječenje primarnog sklerozirajućeg kolangitisa
(Diagnosis and treatment of primary sclerosing cholangitis)

Autori
Mehmedović, Armin ; Nikolić, Marko ; Zekanović, Dražen ; Turčinov, Jadranko ; Ljubičić, Neven

Izvornik
Medica Jadertina (0351-0093) 48 (2018), 1-2; 43-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
primarni sklerozirajući kolangitis ; kolangiopankreatografija magnetskom rezonancijom ; endoskopska retrogradna kolangiopankreatografija ; ...

Sažetak
Primary sclerosing cholangitis (PSC) is a chronic, immune-mediated liver disease. It is characterized by chronic inflammation and fibrosis of intra- and extrahepatic bile ducts. In the course of 10 to 15 years, in most patients the disease leads to decompensated liver cirrhosis due to cholestasis and progressive liver fibrosis. The incidence of primary sclerosing cholangitis is 1 per 100, 000 population. It is estimated that 60% to 80% patients with PSC have inflammatory bowel disease. The etiology of the disease is unclear. At the time of diagnosis, most patients are asymptomatic and only abnormal liver tests and/or the discovery of dilated bile ducts on imaging findings indicate that the disease is present. In symptomatic patients, fatigue and pruritus are the most common symptoms at disease onset. As the disease advances, jaundice, weight loss and abdominal pain occur. The gold standard in diagnosing PSC is magnetic resonance cholangiopancreatography (MRCP), which replaced endoscopic retrograde cholangiopancreatography (ERCP). PSC is treated with ursodeoxycholic acid, ERCP interventions and liver transplant. PSC is a slowly progressive disease and most patients die within 10 to 12 years from the time when the disease was diagnosed, if they do not receive a liver transplant. A significant number of patients develop hepatobiliary or colorectal cancer

Izvorni jezik
Engleski

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