Naslov
Depression, diabetes and expression of cellular adhesion molecules

Autori
Degmečić, Dunja ; Bačun, Tatjana ; Pojatić, Đorđe ; Radoja, Ivan ; Hećimović, Valentina ; Šerić, Vatroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
32nd ECNP Congress / - Kopenhagen : Elsevier, 2019, 240-240

Skup
32nd ECNP Congress

Mjesto i datum
Kopenhagen, Danska, 07.09.2019. - 10.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
depression, diabetes, cell adhesion molecules
(depression, diabetes , cell adhesion molecules)

Sažetak
Background: Cellular adhesion molecules (CAMs) are cell surface molecules crucial for cell trafficking. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin are endothelium derived CAMs. Various factors affect the level of CAMs expression thus changing the inflammatory status. Cell adhesion molecules (CAMs) mediate cell-cell and cell- matrix interactions. Expression of E- and P- selectin, vascular adhesion molecule-1 (VCAM-1), and intracellular adhesion molecule-1 and -2 (ICAM- 1, ICAM-2) on the surface of endothelial cells, as an answer to the pathophysiological stimulants, is considered as a main event in the development of the atherosclerosis. Objective: Determine if there is connection between two groups of patients with type 2 diabetes mellitus and depressive symptoms according to the level of Hba1c ( Hba1c higher than seven, or Hba1c lower than seven) and serum concentration and expression of soluble cellular adhesion molecules (E-selectin, ICAM-1, VCAM-1). Methods: In a prospective study sample consisted of 67 patients with diagnosed type 2 diabetes mellitus. Those patients we divided in two groups according to the level of Hba1c. Group 1 consisted of 37 patients with level HbA1c<7%, and group 2 consisted of 30 patients with level HbA1c= or > 7%. All of them were interviewed and clinically examined by psychiatrist and tested with Mini Mental State Examination (MMSE) , Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA) and sociodemographic questionnaire constructed for this study. Concentration of the soluble cellular adhesion molecules (E-selectin, ICAM-1, VCAM-1) was measured from the blood of the patients and also complete laboratory analysis have been done. Data has been statistically analyzed. Results: Results showed us that patients with higher level of Hba1c had higher level of VCAM-1 molecules at endotel (statistical significance rho=0, 300 p=0, 015, Spearman correlation coefficient) and higher level of E-selectin on the endotel (statistical significance rho=0, 310 p=0, 011, Spearman correlation coefficient) in all 67 patients. Comparation of group 1 (37 patients with level HbA1c<7%) and group 2 (30 patients with level HbA1c= or > 7%) showed that there were no statistical difference in expression of E- selectin (F=1.105, p=0, 265), no statistical difference in expression of ICAM-1 molecules (p=0, 646 Man-Whitney U test), and that there is statistically significant difference between group 1 and group 2 in expression of VCAM-1 molecules (p=0, 039, Man-Whitney U test). Also, results showed us that patients with lower level of homocistein in the plasma were statistically significat more depressed (rho= -0, 264 p=0, 031, Spearman corelation coefficient) in all 67 patients. Conclusion: Altogether our results showed that chronicle hyperglycaemia is significantly correlated with concentration of cellular adhesion molecules ; however there is no correlation with depression. Also, patients with lower level of homocistein in the plasma were statistically significat more depressed. Other similar studies are needed in this field.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA