Naslov
Leitmotif: protein motif scanning 2.0

Autori
Biđin, Siniša ; Vujaklija, Ivan ; Paradžik, Tina ; Bielen, Ana ; Vujaklija, Dušica

Izvornik
Bioinformatics (1367-4803) 36 (2020), 11; 3566-3567

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Leitmotif server ; protein motif scanning

Sažetak
Motivation Motif-HMM (mHMM) scanning has been shown to possess unique advantages over standardly used sequence-profile search methods (e.g. HMMER, PSI-BLAST) since it is particularly well-suited to discriminate proteins with variations inside conserved motifs (e.g. family subtypes) or motifs lacking essential residues (false positives, e.g. pseudoenzymes). Results In order to make mHMM widely accessible to a broader scientific community, we developed Leitmotif, an mHMM web application with many parametrization options easily accessible through intuitive interface. Substantial improvement of performance (ROC scores) was obtained by using two novel parameters. To the best of our knowledge, Leitmotif is the only available mHMM application

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Biologija

POVEZANOST RADA