Naslov
Metal ion-assisted formation of porous chitosan-based microspheres for biomedical applications

Autori
Rogina, Anamarija ; Vidović, Dorina ; Antunović, Maja ; Ivanković, Marica ; Ivanković, Hrvoje

Izvornik
International journal of polymeric materials and polymeric biomaterials (0091-4037) 70 (2021), 14; 1027-1035

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chitosan ; complex ; copper ; cytotoxicity ; microspheres ; zinc

Sažetak
As a poly(D-glucosamine), chitosan possesses the ability to chelate bioactive metal ions such as copper and zinc. In this work, metal ion containing microspheres were formed through complexation interactions between glucosamine unit of chitosan and copper and zinc ions, respectively. The successful production of chitosan‒metal ion microspheres was done by high- voltage electrostatic system. The produced microspheres showed a narrow size distribution with average size range of 100–240 µm. The cytotoxicity evaluation of direct cells‒ materials contact indicated no toxicity of chitosan–Zn2+ microspheres, while chitosan‒Cu2+ microspheres containing higher c(Cu2+) were cytotoxic for Hek293 cells during 3 days of culture.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Kemijsko inženjerstvo, Temeljne tehničke znanosti, Interdisciplinarne tehničke znanosti

POVEZANOST RADA