Naslov
Adenylosuccinate synthetase from pathogen Helicobacter pylori

Autori
Bubić, Ante ; Leščić Ašler, Ivana ; Bertoša, Branimir ; Luić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Structural Bioinformatics

Mjesto i datum
Hinxton, Ujedinjeno Kraljevstvo, 16.09.2019. - 20.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
EMBL ; EBI ; Bioniformatics ; Structural

Sažetak
Helicobacter pylori is a Gram-negative microaerophilic bacterium that chronically colonizes the gastric epithelium. This pathogen is responsible for the development of several gastrointestinal diseases ; including non-symptomatic chronic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. Adenylosuccinate synthetase (AdSS) is one of the essential enzymes in purine salvage pathway. It is a ligase which catalyzes the condensation of IMP with L-aspartate to form adenylosuccinate by hydrolyzing GTP in the presence of Mg 2+ ions. Since Helicobacter pylori lacks the genes for de novo synthesis of purines, as shown in bioinformatic studies, AdSS is a potential drug target. The aim of the project is biochemical and structural characterization of this enzyme and to find potential new inhibitors, which could be efficient in eradication of this pathogen.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA