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Pregled bibliografske jedinice broj: 1067656

Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

Dvojković, Anja; Nikolac Perković, Matea; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Švob Štrac, Dubravka; Vuksan Ćusa, Bjanka; Tudor, Lucija; Kušević, Zorana; Konjevod, Marcela et al.
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients // Progress in neuro-psychopharmacology & biological psychiatry, 105 (2021), 110016, 30 doi:10.1016/j.pnpbp.2020.110016 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1067656 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

Autori
Dvojković, Anja ; Nikolac Perković, Matea ; Šagud, Marina ; Nedić Erjavec, Gordana ; Mihaljević Peleš, Alma ; Švob Štrac, Dubravka ; Vuksan Ćusa, Bjanka ; Tudor, Lucija ; Kušević, Zorana ; Konjevod, Marcela ; Živković, Maja ; Jevtović, Saša ; Pivac, Nela

Izvornik
Progress in neuro-psychopharmacology & biological psychiatry (0278-5846) 105 (2021); 110016, 30

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
depression ; escitalopram ; plasma BDNF ; platelet serotonin ; patients ; vortioxetine

Sažetak
Escitalopram and vortioxetine are efficacious antidepressants. They directly target serotonin (5-HT) system, but vortioxetine mechanism of action is distinct from the one of selective serotonin reuptake inhibitors (SSRIs). Treatment with SSRIs decrease platelet 5-HT concentration and increase peripheral brain- derived neurotrophic factor (BDNF) levels. Since vortioxetine has a multimodal mechanism of action, it is expected to have a greater effect on circulatory BDNF concentration, compared to conventional antidepressants. This longitudinal study aimed to explore and compare the effects of 4-weeks of treatment with vortioxetine and escitalopram on plasma BDNF and platelet 5-HT concentration in patients with major depressive disorder (MDD). The results revealed that vortioxetine significantly increased plasma BDNF concentration (p=0.018) and significantly decreased platelet 5-HT concentration (p<0.001). Treatment with escitalopram significantly decreased platelet 5-HT concentration (p <0.001), but it did not affect plasma BDNF concentration (p=0.379). Response to vortioxetine was not predicted by baseline plasma BDNF or platelet 5-HT concentration, but response to escitalopram was predicted by baseline platelet 5-HT concentration. These effects might be due to vortioxetine unique mechanism of action, but the clinical implications are unclear. It remains to be determined whether this finding extends during long-term vortioxetine treatment, and which, if any, clinical effects emerge from BDNF increase.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Anja Dvojković (autor)

Avatar Url Gordana Nedić Erjavec (autor)

Avatar Url Marina Šagud (autor)

Avatar Url Nela Pivac (autor)

Avatar Url Saša Jevtović (autor)

Avatar Url Maja Živković (autor)

Avatar Url Marcela Konjevod (autor)

Avatar Url Zorana Kušević (autor)

Avatar Url Alma Mihaljević-Peleš (autor)

Avatar Url Dubravka Švob Štrac (autor)

Avatar Url Lucija Tudor (autor)

Avatar Url Matea Nikolac Perković (autor)

Avatar Url Bjanka Vuksan-Ćusa (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Dvojković, Anja; Nikolac Perković, Matea; Šagud, Marina; Nedić Erjavec, Gordana; Mihaljević Peleš, Alma; Švob Štrac, Dubravka; Vuksan Ćusa, Bjanka; Tudor, Lucija; Kušević, Zorana; Konjevod, Marcela et al.
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients // Progress in neuro-psychopharmacology & biological psychiatry, 105 (2021), 110016, 30 doi:10.1016/j.pnpbp.2020.110016 (međunarodna recenzija, članak, znanstveni)
Dvojković, A., Nikolac Perković, M., Šagud, M., Nedić Erjavec, G., Mihaljević Peleš, A., Švob Štrac, D., Vuksan Ćusa, B., Tudor, L., Kušević, Z. & Konjevod, M. (2021) Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients. Progress in neuro-psychopharmacology & biological psychiatry, 105, 110016, 30 doi:10.1016/j.pnpbp.2020.110016.
@article{article, author = {Dvojkovi\'{c}, Anja and Nikolac Perkovi\'{c}, Matea and \v{S}agud, Marina and Nedi\'{c} Erjavec, Gordana and Mihaljevi\'{c} Pele\v{s}, Alma and \v{S}vob \v{S}trac, Dubravka and Vuksan \'{C}usa, Bjanka and Tudor, Lucija and Ku\v{s}evi\'{c}, Zorana and Konjevod, Marcela and \v{Z}ivkovi\'{c}, Maja and Jevtovi\'{c}, Sa\v{s}a and Pivac, Nela}, year = {2021}, pages = {30}, DOI = {10.1016/j.pnpbp.2020.110016}, chapter = {110016}, keywords = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2020.110016}, volume = {105}, issn = {0278-5846}, title = {Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients}, keyword = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine}, chapternumber = {110016} }
@article{article, author = {Dvojkovi\'{c}, Anja and Nikolac Perkovi\'{c}, Matea and \v{S}agud, Marina and Nedi\'{c} Erjavec, Gordana and Mihaljevi\'{c} Pele\v{s}, Alma and \v{S}vob \v{S}trac, Dubravka and Vuksan \'{C}usa, Bjanka and Tudor, Lucija and Ku\v{s}evi\'{c}, Zorana and Konjevod, Marcela and \v{Z}ivkovi\'{c}, Maja and Jevtovi\'{c}, Sa\v{s}a and Pivac, Nela}, year = {2021}, pages = {30}, DOI = {10.1016/j.pnpbp.2020.110016}, chapter = {110016}, keywords = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2020.110016}, volume = {105}, issn = {0278-5846}, title = {Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients}, keyword = {depression, escitalopram, plasma BDNF, platelet serotonin, patients, vortioxetine}, chapternumber = {110016} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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