Naslov
Lower urine uromodulin is associated with trend to lower sodium excretion in middle-aged subjects

Autori
Josipović, Josipa ; Šimičević, Livija ; Miličić, Borna ; Vrkić, Nada ; Boban, Marko ; Vrsalović, Mislav ; Pavlović, Nikola ; Bulj, Nikola ; Trbušić, Matias ; Delić-Brkljačić, Diana ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Hypertension / - Los Angeles (CA) : OMICS Publishing Group, 2019, E318-e318

Skup
29th European Meeting on Hypertension and Cardiovascular Protection (ESH 2019)

Mjesto i datum
Milano, Italija, 21.06.2019. - 24.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
uromodulin ; gene polymorphisms ; hypertension ; chronic kidney disease

Sažetak
Objective: Recent GWAS studies found uromodulin gene polymorphisms to be associated with increased risk for hypertension (HT) and chronic kidney disease. It was hypothesized that relation of uromodulin with HT might be through effects on sodium renal excretion. Our aim was to analyse association of urinary uromodulin concentrations (uUMc) with blood pressure (BP) and sodium excretion in a group of untreated middle-aged subjects. Design and method: In this cross-sectional study 175 apparently healthy untreated subjects without a history for CV and with eGFR> 60 ml/min/1.73 m2 were enrolled. Fasting blood and urine 24-hour urine sample were obtained and BP was measured following ESH/ESC guidelines in office (Omron M6) and during regular working (ABPM: Mobile-O-Graph). Based on office BP subjects were divided according to the JNC-7 classification. Uromodulin was determined by Enzyme

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA