Naslov
Phenotype variants of invasive breast cancer differ in associations between the primary tumor size and its Ki-67 value.

Autori
Kurbel, Sven ; Dmitrović, Branko ; Vrbanec, Damir ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni

Izvornik
Journal of Clinical Oncology 2020 ; 38:15(suppl) / - Alexandria (VA) : American Society of Clinical Oncology, 2020

Skup
Annual Meeting (ASCO 2020)

Mjesto i datum
Chicago (IL), Sjedinjene Američke Države, 29.05.2020. - 31.05.2020

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
breast neoplasms, Ki-67 Antigen

Sažetak
Background: Epidemiological studies report that Ki-67 values are higher in larger invasive breast cancers (IBC). This relation was investigated in 1040 consecutive IBC patients with various immunohistological phenotypes (ER+/- ; HER2 0, 1+ to 3+), all treated at a single Croatian hospital. Methods: A scatter plot of 1040 Ki-67 values with their cancer diameter (in cms) have produced an LOWESS nonparametric curve that almost overlapped with the logarithmic function of the same data set (Ki-67% = 18.39+20.63*log(D), where D is a tumor diameter in cm). The next step in using this logarithmic function as a model, was to convert D values into log(D) for linear correlations, amenable to tests of significance. Results: Among all 1040 pts, only ER positive phenotype variants Ki-67% correlated with log(D): Among ER positive tumors, the HER2 expression has decreased the correlation significance and the slope of regression lines, suggesting that the HER2 presence increases Ki67% in small tumors, while larger tumors have Ki67% less augmented than among HER2 absent tumors. Thus the highest slope of the line was found among HER2 absent ER+ patients. Conclusions: Since only ER positive tumors have shown correlation of Ki67% with the log of their tumor size, tumor biology (estimated by Ki67%) of the ER negative IBCs seems unrelated with their size. This possibly suggests that the clinical course of ER negative IBC patients is less predictable due to some etiological distinction the ER positive and ER negative breast cancers. ERstatus ERpositive tumors ERnegative tumors Allpatients HER2status 0 1+or 2+ 3+ 0 1+or 2+ 3+ IBCtype LuminalA or B1 LuminalB2 Triplenegative pureHER2 Numberof pts. 320 313 172 89 46 100 1040 Pearson’slinear correlation between log(D) and Ki67%: y = k*x+l k(slope) 21.9289 13.8523 13.1247 20.5867 -4.9062 2.5887 20.6302 l(intercept) 10.8254 13.6766 21.0642 44.0372 46.5005 33.7856 18.3922 r 0.3451 0.2217 0.1767 0.1730 -0.0366 0.0326 0.2275 p < 0.0001 0.00008 0.0204 0.1050 0.8094 0.7474 < 0.0001)

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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