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Pregled bibliografske jedinice broj: 1063358

Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice

Thyssen, Jacob P.; Jakasa, Ivone; Riethmüller, Christoph; Schön, Michael P.; Braun, Andrea; Haftek, Marek; Fallon, Padraic G.; Wróblewski, Jacek; Jakubowski, Hieronim; Eckhart, Leopold et al.
Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice // Journal of Investigative Dermatology, 140 (2020), 3; 615-623e5 doi:10.1016/j.jid.2019.07.716 (međunarodna recenzija, članak, znanstveni)

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Naslov
Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice

Autori
Thyssen, Jacob P. ; Jakasa, Ivone ; Riethmüller, Christoph ; Schön, Michael P. ; Braun, Andrea ; Haftek, Marek ; Fallon, Padraic G. ; Wróblewski, Jacek ; Jakubowski, Hieronim ; Eckhart, Leopold ; Declercq, Wim ; Koppes, Sjors ; Engebretsen, Kristiane A. ; Bonefeld, Charlotte ; Irvine, Alan D. ; Keita-Alassane, Sokhna ; Simon, Michel ; Kawasaki, Hiroshi ; Kubo, Akiharu ; Amagai, Masayuki ; Matsui, Takeshi ; Kezic, Sanja

Izvornik
Journal of Investigative Dermatology (0022-202X) 140 (2020), 3; 615-623e5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
filaggrin expression, natural moisturizing factor, dermal texture index, mouse models, cell stiffness

Sažetak
Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with filaggrin loss-of-function mutations, are inversely associated with levels of natural moisturizing factors (NMFs) in the stratum corneum. To dissect the etiological role of NMFs and filaggrin deficiency in surface texture alterations, we examined mouse models with genetic deficiencies in the synthesis or degradation of filaggrin monomers for NMFs, cell stiffness (elastic modulus) and corneocyte surface protrusion density (dermal texture index). Five neonatal and adult mouse models carrying inactivating mutations of SASPase (Sasp−/−), filaggrin (Flgft/ft and Flg−/−), filaggrin-hornerin (FlgHrnr−/−), and bleomycin hydrolase (Blmh−/−) were investigated. Sasp−/− and Flg−/− were on the hairless mouse background. Atomic force microscopy was used to determine elastic modulus and dermal texture index. Corneocytes of each neonatal as well as hairless adult knockout mouse exhibited an increased number of protrusions and decreased elastic modulus. In these mice, NMFs were reduced except for Sasp−/−. Dermal texture index was inversely correlated with NMFs and elastic modulus. Our findings demonstrate that any filaggrin-NMF axis deficiency can affect corneocyte mechanical properties in mice and likely in humans. Differences in NMFs and corneocyte surface texture between neonatal and adult as well as hairless and hairy mice emphasize the need for carefully selecting the most appropriate animal models for studies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA

Profili:

Avatar Url Ivone Jakasa (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Thyssen, Jacob P.; Jakasa, Ivone; Riethmüller, Christoph; Schön, Michael P.; Braun, Andrea; Haftek, Marek; Fallon, Padraic G.; Wróblewski, Jacek; Jakubowski, Hieronim; Eckhart, Leopold et al.
Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice // Journal of Investigative Dermatology, 140 (2020), 3; 615-623e5 doi:10.1016/j.jid.2019.07.716 (međunarodna recenzija, članak, znanstveni)
Thyssen, J., Jakasa, I., Riethmüller, C., Schön, M., Braun, A., Haftek, M., Fallon, P., Wróblewski, J., Jakubowski, H. & Eckhart, L. (2020) Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice. Journal of Investigative Dermatology, 140 (3), 615-623e5 doi:10.1016/j.jid.2019.07.716.
@article{article, author = {Thyssen, Jacob P. and Jakasa, Ivone and Riethm\"{u}ller, Christoph and Sch\"{o}n, Michael P. and Braun, Andrea and Haftek, Marek and Fallon, Padraic G. and Wr\'{o}blewski, Jacek and Jakubowski, Hieronim and Eckhart, Leopold and Declercq, Wim and Koppes, Sjors and Engebretsen, Kristiane A. and Bonefeld, Charlotte and Irvine, Alan D. and Keita-Alassane, Sokhna and Simon, Michel and Kawasaki, Hiroshi and Kubo, Akiharu and Amagai, Masayuki and Matsui, Takeshi and Kezic, Sanja}, year = {2020}, pages = {615-623e5}, DOI = {10.1016/j.jid.2019.07.716}, keywords = {filaggrin expression, natural moisturizing factor, dermal texture index, mouse models, cell stiffness}, journal = {Journal of Investigative Dermatology}, doi = {10.1016/j.jid.2019.07.716}, volume = {140}, number = {3}, issn = {0022-202X}, title = {Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice}, keyword = {filaggrin expression, natural moisturizing factor, dermal texture index, mouse models, cell stiffness} }
@article{article, author = {Thyssen, Jacob P. and Jakasa, Ivone and Riethm\"{u}ller, Christoph and Sch\"{o}n, Michael P. and Braun, Andrea and Haftek, Marek and Fallon, Padraic G. and Wr\'{o}blewski, Jacek and Jakubowski, Hieronim and Eckhart, Leopold and Declercq, Wim and Koppes, Sjors and Engebretsen, Kristiane A. and Bonefeld, Charlotte and Irvine, Alan D. and Keita-Alassane, Sokhna and Simon, Michel and Kawasaki, Hiroshi and Kubo, Akiharu and Amagai, Masayuki and Matsui, Takeshi and Kezic, Sanja}, year = {2020}, pages = {615-623e5}, DOI = {10.1016/j.jid.2019.07.716}, keywords = {filaggrin expression, natural moisturizing factor, dermal texture index, mouse models, cell stiffness}, journal = {Journal of Investigative Dermatology}, doi = {10.1016/j.jid.2019.07.716}, volume = {140}, number = {3}, issn = {0022-202X}, title = {Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice}, keyword = {filaggrin expression, natural moisturizing factor, dermal texture index, mouse models, cell stiffness} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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