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Pregled bibliografske jedinice broj: 1061975

Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia

D'Onofrio, Valentino; Conzemius, Rick; Varda- Brkić, Dijana; Bogdan, Maja; Grisold, Andrea; Gyssens, Inge; Bedenić, Branka; Barišić, Ivan
Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia // Infection, genetics and evolution, 81 (2020), 104263, 10 doi:10.1016/j.meegid.2020.104263 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1061975 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia

Autori
D'Onofrio, Valentino ; Conzemius, Rick ; Varda- Brkić, Dijana ; Bogdan, Maja ; Grisold, Andrea ; Gyssens, Inge ; Bedenić, Branka ; Barišić, Ivan

Izvornik
Infection, genetics and evolution (1567-1348) 81 (2020); 104263, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acinetobacter baumannii ; carbapenems ; carbapenem-hydrolyzing oxacillinase ; resistance ; klebsiella pneumoniae ; colistin resistance

Sažetak
Colistin is a last-resort antibiotic for the treatment of infections caused by multidrug and carbapenem-resistant Gram-negative bacteria. Colistin resistance has been emerging and multiple outbreaks have been reported in Europe. It has been mostly reported in carbapenem-resistant K. pneumoniae. In this study, 24 multidrug and colistin-resistant clinical isolates (14 K. pneumoniae, one E. aerogenes, one E. cloacae, and eight A. baumannii) were collected from 4 hospitals in Croatia from 2013 to 2018, to describe the epidemiology and mechanisms of antibiotic resistance. β-lactamase and carbapenemase genes were detected by PCR. Genotyping was done with rep-PCR. Whole genome sequencing was performed to discover possible molecular mechanisms for the observed colistin resistance. All isolates, except one, were extensively drug resistant. Ten out of 16 (63%) K. pneumoniae isolates possessed blaOXA-48, which is the most common carbapenem resistance gene in Croatia and elsewhere in Europe. All A. baumanni isolates possessed OXA-23-like carbapenem hydrolyzing oxacillinase. Colistin resistance was most likely chromosomally mediated. After sequence analysis, none of the isolates were found to possess any of the mcr gene variants. Several previously reported amino acid changes were found in PmrB, PhoP, PhoQ, MgrB, and LpxC, which are associated with colistin resistance. Most importantly, the presence of colistin resistance together with carbapenemase genes in extensively drug resistant isolates poses real threats in the use of carbapenems and colistin to fight infections.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
FAPIC-634137

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Maja Bogdan (autor)

Avatar Url Ivan Barišić (autor)

Avatar Url Branka Bedenić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

D'Onofrio, Valentino; Conzemius, Rick; Varda- Brkić, Dijana; Bogdan, Maja; Grisold, Andrea; Gyssens, Inge; Bedenić, Branka; Barišić, Ivan
Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia // Infection, genetics and evolution, 81 (2020), 104263, 10 doi:10.1016/j.meegid.2020.104263 (međunarodna recenzija, članak, znanstveni)
D'Onofrio, V., Conzemius, R., Varda- Brkić, D., Bogdan, M., Grisold, A., Gyssens, I., Bedenić, B. & Barišić, I. (2020) Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia. Infection, genetics and evolution, 81, 104263, 10 doi:10.1016/j.meegid.2020.104263.
@article{article, author = {D'Onofrio, Valentino and Conzemius, Rick and Varda- Brki\'{c}, Dijana and Bogdan, Maja and Grisold, Andrea and Gyssens, Inge and Bedeni\'{c}, Branka and Bari\v{s}i\'{c}, Ivan}, year = {2020}, pages = {10}, DOI = {10.1016/j.meegid.2020.104263}, chapter = {104263}, keywords = {Acinetobacter baumannii, carbapenems, carbapenem-hydrolyzing oxacillinase, resistance, klebsiella pneumoniae, colistin resistance}, journal = {Infection, genetics and evolution}, doi = {10.1016/j.meegid.2020.104263}, volume = {81}, issn = {1567-1348}, title = {Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia}, keyword = {Acinetobacter baumannii, carbapenems, carbapenem-hydrolyzing oxacillinase, resistance, klebsiella pneumoniae, colistin resistance}, chapternumber = {104263} }
@article{article, author = {D'Onofrio, Valentino and Conzemius, Rick and Varda- Brki\'{c}, Dijana and Bogdan, Maja and Grisold, Andrea and Gyssens, Inge and Bedeni\'{c}, Branka and Bari\v{s}i\'{c}, Ivan}, year = {2020}, pages = {10}, DOI = {10.1016/j.meegid.2020.104263}, chapter = {104263}, keywords = {Acinetobacter baumannii, carbapenems, carbapenem-hydrolyzing oxacillinase, resistance, klebsiella pneumoniae, colistin resistance}, journal = {Infection, genetics and evolution}, doi = {10.1016/j.meegid.2020.104263}, volume = {81}, issn = {1567-1348}, title = {Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia}, keyword = {Acinetobacter baumannii, carbapenems, carbapenem-hydrolyzing oxacillinase, resistance, klebsiella pneumoniae, colistin resistance}, chapternumber = {104263} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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