Pregled bibliografske jedinice broj: 1061454
Calculation of pKa of arachidic acid in DOPC phospholipid bilayer
Calculation of pKa of arachidic acid in DOPC phospholipid bilayer // The Spring School in Computational Chemistry
Espoo, Finska, 2017. (poster, nije recenziran, ostalo)
CROSBI ID: 1061454 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Calculation of pKa of arachidic acid in DOPC
phospholipid bilayer
Autori
Škulj, Sanja ; Vazdar, Mario
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, ostalo
Skup
The Spring School in Computational Chemistry
Mjesto i datum
Espoo, Finska, 14.03.2017. - 17.03.2017
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
long chain fatty acids ; proton tranfer ; pKa
Sažetak
Fatty acids (FA) are important nutrients which regulate the storage and energy resources in living systems. FAs diffuse through phospholipid bilayers and affect the biophysical properties of the mitochondrial inner membrane by increasing H+ conductance across the bilayer. Long-chain FAs activate uncoupling proteins (UCPs) embedded in biological membranes - in particular, FAs increase the UCP1 and UCP2 dependent H+ leak. In order to understand the details of the H+ transport, we considered neutral and deprotonated form of C20:0 arachidic acid and calculated free energy profiles to determine its pKa inside the DOPC bilayer thus shedding more light on this important biophysical phenomena.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-UIP-2014-09-6090 - Molekularni aspekti oksidativnih procesa u stanicama (MolOxStress) (Vazdar, Mario, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
