Naslov
Review of recent advances in preimplantation genetic diagnosis

Autori
Medač Petra, Čorak Daniel, Anđić Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Jurić, Ivana ; Pušeljić, Nora ; Švitek, Luka - Osijek, 2020, 71-71

Skup
2nd International Translational Medicine Congress of Students and Young Physicians (OSCON 2020)

Mjesto i datum
Osijek, Hrvatska, 13.02.2020. - 14.02.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
preimplantation genetic diagnosis (PGD) ; preimplantation genetic screening (PGS), preimplantation genetic testing (PGT) ; in vitro fertilization (IVF)

Sažetak
Invasive procedures, i.e., trophectoderm, blastomere and polar body biopsy require removal of the cells from preimplantation embryos and it’s considered that they have an adverse impact on the development of an embryo. However, it has been proven that the use of laser manipulation on biopsy karyotype doesn’t have a negligible impact on PGS results, but it is yet unknown how it can affect the embryo viability. Meanwhile, several new procedures were introduced into the field including time- lapse technology, blastocoel fluid sampling and cell-free nucleic acid collection from the spent culture medium. These methods have limitations and require further examination and validation for their clinical use. Furthermore, it has been proven that results about aneuploidy obtained from the spent culture medium and blastocoel fluid differ. Thankfully to the rapid development of PGD/PGS, there are reports of a few cases of healthy baby deliveries. For example, while the mother is a carrier of X-linked disease, mucopolysaccharidosis type II, the male baby was born healthy. In addition to that, PGT is a successful method to determinate aneuploid pregnancy of women of AMA that undergo IVF. According to research conducted on 627 women, clinical pregnancy rates were higher after elective single embryo transfer versus non- elective.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA