Naslov
Cluster analysis of chronic rhinosinusitis suggests gender-based differences

Autori
Jurlin, Lana ; Gregurić, Tomislav ; Baudoin, Tomislav ; Grgić, Marko Velimir ; Pažanin, Leo ; Košec, Andro ; Scadding, Glenis ; Kalogjera, Livije

Izvornik
ORL (0301-1569) 81 (2018), 1; 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic rhinosinusitis ; computerized tomography ; nasal polyps ; sino-nasal outcome test 22 ; visual analog scale score

Sažetak
We aimed to evaluate the interaction between the overall severity of chronic rhinosinusitis (CRS) before treatment and subjective improvement following surgical or medical treatment. A group of 97 patients with CRS completed the visual analog scale (VAS) symptom score and the Sino-Nasal Outcome Test 22 (SNOT-22) questionnaire in the moment of their sinus computerized tomography (CT) scan. Data were analyzed via a 2-step cluster analysis based on gender, polyp presence, CT scan, and VAS scores for symptoms. There were 3 clusters: the first cluster comprised 37 female patients with CRS without nasal polyps (CRSsNP), the second cluster comprised 30 patients with CRS and NP (CRSwNP ; 15 males and 15 females) ; and third cluster had 30 male patients with CRS without NP (CRSsNP). Different symptom patterns between clusters were identified. After adjustment for polyp presence, gender, eosinophilia (p = 0.021), and the SNOT-22 score (p = 0.005) were found to be better outcome predictors than the CT score (p = 0.26). Long-term patient satisfaction is significantly associated with the subjective symptom severity prior to treatment, i.e., postnasal drip and overall disease severity (SNOT-22 score), but not with the objective severity of the disease (CT score and inflammation).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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