Naslov
Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity

Autori
Mandić, Leo ; Benčić, Patricia ; Mlinarić-Majerski, Kata ; Liekens, Sandra ; Snoeck, Robert ; Andrei, Graciela ; Kralj, Marijeta ; Basarić, Nikola

Izvornik
Archiv der Pharmazie (0365-6233) 353 (2020), 6; 2000024, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adamantane ; Antiproliferative activity ; Antiviral activity ; Phthalimide

Sažetak
Three groups of adamantylphthalimides, bearing different substituents at the phthalimide moiety, N-(4′-R2)phthalimidoadamantanes, 1-7, 3-[N-(4′-R2)phthalimido]-1-adamantanols, 8-10 and 3-[N-(4′-R2)phthalimido]adamantane-1-carboxylic acids 11-15, were synthesized and screened against tumor cells and viruses. The most potent compounds are not substituted at the adamantane and bear OH or NH2 substituent at the phthalimide (compounds 3 and 5). The antiproliferative activity of 3 and 5 is in micromolar range, much higher than the one of thalidomide. Minor antiviral activity against cytomegalovirus and varicella-zoster virus was found for 3 and 5 but these compounds lacked selectivity. The results presented are important for the rational design of next generation of compounds with anticancer and antiviral activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA