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Pregled bibliografske jedinice broj: 1056367

Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development

Popovitchenko, Tatiana; Park, Yongkyu; Page, Nicholas F.; Luo, Xiaobing; Krsnik, Zeljka; Liu, Yuan; Salamon, Iva; Stephenson, Jessica D.; Kraushar, Matthew L.; Volk, Nicole L. et al.
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development // Nature communications, 11 (2020), 1; 1-21 doi:10.1038/s41467-020-15412-8 (međunarodna recenzija, članak, znanstveni)

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Naslov
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development
(Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development)

Autori
Popovitchenko, Tatiana ; Park, Yongkyu ; Page, Nicholas F. ; Luo, Xiaobing ; Krsnik, Zeljka ; Liu, Yuan ; Salamon, Iva ; Stephenson, Jessica D. ; Kraushar, Matthew L. ; Volk, Nicole L. ; Patel, Sejal M. ; Wijeratne, H. R. Sagara ; Li, Diana ; Suthar, Kandarp S. ; Wach, Aaron ; Sun, Miao ; Arnold, Sebastian J. ; Akamatsu, Wado ; Okano, Hideyuki ; Paillard, Luc ; Zhang, Huaye ; Buyske, Steven ; Kostovic, Ivica ; De Rubeis, Silvia ; Hart, Ronald P. ; Rasin, Mladen-Roko

Izvornik
Nature communications (2041-1723) 11 (2020), 1; 1-21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CELF1, RNA-binding protein, neurodevelopment

Sažetak
Neurodevelopment requires precise regulation of gene expression, including post-transcriptional regulatory events such as alternative splicing and mRNA translation. However, translational regulation of specific isoforms during neurodevelopment and the mechanisms behind it remain unknown. Using RNA-seq analysis of mouse neocortical polysomes, here we report translationally repressed and derepressed mRNA isoforms during neocortical neurogenesis whose orthologs include risk genes for neurodevelopmental disorders. We demonstrate that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5′ UTRs. Furthermore, 5′ UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons. Our findings reveal a dynamic interplay between distinct RBPs and alternative 5′ UTRs in neuronal development and underscore the risk of post-transcriptional dysregulation in co-occurring neurodevelopmental disorders.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
PSZ-2019-02-4710

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ivica Kostović (autor)

Avatar Url Željka Krsnik (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Popovitchenko, Tatiana; Park, Yongkyu; Page, Nicholas F.; Luo, Xiaobing; Krsnik, Zeljka; Liu, Yuan; Salamon, Iva; Stephenson, Jessica D.; Kraushar, Matthew L.; Volk, Nicole L. et al.
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development // Nature communications, 11 (2020), 1; 1-21 doi:10.1038/s41467-020-15412-8 (međunarodna recenzija, članak, znanstveni)
Popovitchenko, T., Park, Y., Page, N., Luo, X., Krsnik, Z., Liu, Y., Salamon, I., Stephenson, J., Kraushar, M. & Volk, N. (2020) Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development. Nature communications, 11 (1), 1-21 doi:10.1038/s41467-020-15412-8.
@article{article, author = {Popovitchenko, Tatiana and Park, Yongkyu and Page, Nicholas F. and Luo, Xiaobing and Krsnik, Zeljka and Liu, Yuan and Salamon, Iva and Stephenson, Jessica D. and Kraushar, Matthew L. and Volk, Nicole L. and Patel, Sejal M. and Wijeratne, H. R. Sagara and Li, Diana and Suthar, Kandarp S. and Wach, Aaron and Sun, Miao and Arnold, Sebastian J. and Akamatsu, Wado and Okano, Hideyuki and Paillard, Luc and Zhang, Huaye and Buyske, Steven and Kostovic, Ivica and De Rubeis, Silvia and Hart, Ronald P. and Rasin, Mladen-Roko}, year = {2020}, pages = {1-21}, DOI = {10.1038/s41467-020-15412-8}, keywords = {CELF1, RNA-binding protein, neurodevelopment}, journal = {Nature communications}, doi = {10.1038/s41467-020-15412-8}, volume = {11}, number = {1}, issn = {2041-1723}, title = {Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development}, keyword = {CELF1, RNA-binding protein, neurodevelopment} }
@article{article, author = {Popovitchenko, Tatiana and Park, Yongkyu and Page, Nicholas F. and Luo, Xiaobing and Krsnik, Zeljka and Liu, Yuan and Salamon, Iva and Stephenson, Jessica D. and Kraushar, Matthew L. and Volk, Nicole L. and Patel, Sejal M. and Wijeratne, H. R. Sagara and Li, Diana and Suthar, Kandarp S. and Wach, Aaron and Sun, Miao and Arnold, Sebastian J. and Akamatsu, Wado and Okano, Hideyuki and Paillard, Luc and Zhang, Huaye and Buyske, Steven and Kostovic, Ivica and De Rubeis, Silvia and Hart, Ronald P. and Rasin, Mladen-Roko}, year = {2020}, pages = {1-21}, DOI = {10.1038/s41467-020-15412-8}, keywords = {CELF1, RNA-binding protein, neurodevelopment}, journal = {Nature communications}, doi = {10.1038/s41467-020-15412-8}, volume = {11}, number = {1}, issn = {2041-1723}, title = {Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development}, keyword = {CELF1, RNA-binding protein, neurodevelopment} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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