Naslov
Clinical efficiacy of PDTC in foals challenged with Equine influenza (EI) virus

Autori
Grden, Darko, Van den Hoven, Rene

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Handbook of presentations & free communications / - Fordham : Equine Veterinary Journal, Ltd, Newmarket, 2006, 205-205

Skup
45th Congress Brittish Equine Veterinary Association

Mjesto i datum
Birmingham, Ujedinjeno Kraljevstvo, 13.09.2006. - 16.09.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Horse, Inluenza, PDTC, Foals

Sažetak
The clinical efficacy of pyrrolidine dithiocarbamate (PDTC) and the effects on virus replication was tested in 10 sero-negative foals that were experimentally infected with El virus. Six-to 12-month-old foals were randomly allocated into a treatment (T) and a control group (C). On Day O all foals were exposed to an aerosol challenge with 10^6 EID50/ml of an A/equi2 (H3N8) isolate. Subsequently, the T group was nebulised twice daily for 5 days with 5 ml of an aerosol containing 2.5 mmol/l PDTC, beginning from the morning of Day 3 till the evening on Day 7. Foals were clinically examined daily and composite clinical scores, based on appetite, demeanour, respiratory signs, nasal discharge, ocular discharge, coughing and mandibular lymph node enlargement, were recorded. Samples for total and differential white blood cell count (TWBC, DWBC) were taken on Days 0, 4, 8, and 16. Nasopharyngeal swabs for viral excretion were taken daily and the sera were tested on Day 16 for sero-conversion to El virus. Four out of 5 foals in each group had become sero-positive for El virus. None of the HI titres exceeded 1:512 and only 2 foals, both in the T group, excreted low levels of virus. Foals in both groups had secondary complications with S. equi. All sero-positive foals showed marked increase in TWBC, and there was a significant difference between T and C group for TWBC and fibrinogen level (P = 0.0475). The clinical score did not show any significant difference between T and C group, however lymph nodes appeared markedly enlarged. Differences found between T and C group indicate that PDTC could modify clinical symptoms of a mild El infection and its secondary complications. In further investigations a more severe challenge should be used.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA