Naslov
Vitamin D3 as a Powerful Immunoregulator - Cause or Consequence of Disbalance?

Autori
Miskic B*1, Rajkovaca I2 and Cosic V

Izvornik
Biomedical Journal of Scientific & Technical Research (2574-1241) 9 (2018), 2; 1-3

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vitamin D3 immunoregulator, cause, consqeences

Sažetak
Vitamin D3 has been recognized not only as a regulatory component of a bone - kidney metabolism, but also as an important immunomodulator. When vitamin D3 interacts with VDR surface, VDR binds to regulatory regions of target genes and acts to nucleate the formation of large protein complexes whose activation is essential for changes in transcription. Estimated level of vitamin D is only current states indicator. We still don’t know which serum level is a trigger for cell state change and how long it takes for a certain serum level to cause conformational changes of receptors following changes in protein synthesis. Answers to those questions can be found in the newest intracellular researches including VDR and its molecular mechanism of action at target genes and how vitamin D3-activated VDR modulates the expression of genes at both single gene and also at the level of gene networks. Only randomized controlled trials which will study intrageneric mutations mentioned previously can give us the answer if vitamin D is the main supervisor of intracellular metabolism or is it one of many cofactors.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA